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  • HVA  (1)
  • Keywords: HIV vaccines; HIV antibodies; gp120; gp41; Pepscan; statistical data analysis  (1)
  • Refractory depression  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Reserpine augmentation of desipramine in refractory depression: clinical and neurobiological effects (1987)
    Springer
    Psychopharmacology 92 (1987), S. 431-437 
    Details
    ISSN: 1432-2072
    Keywords: Reserpine ; Desipramine ; Antidepressants ; Refractory depression ; MHPG ; HVA ; 5-HIAA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Early studies showed dramatic improvement in some depressed patients when a brief course of parenteral reserpine was added to ineffective tricyclic antidepressant (TCA) treatment. We treated eight patients with DSM-III melancholic major depression with desipramine (DMI)≥2.5 mg/kg/day (plasma levels〉125 ng/ml) for at least 4 weeks. All patients failed to respond and received reserpine 5 mg IM b.i.d. over 2 days, in seven cases as a placebo-controlled, double-blind trial. One patient had dramatic resolution of depressive and psychotic symptoms within 48 h, but relapsed within 2 weeks; two other patients had transient hypomanic symptoms. Depression ratings did not significantly change for the sample as a whole, but plasma and cerebrospinal fluid (CSF) levels of 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) decreased and CSF levels of homovanillic acid (HVA) and 5-hydroxy-indoleacetic acid (5-HIAA) increased. Despite robust effects on central monoamine metabolism, reserpine augmentation appears insufficiently effective for routine use in managing refractory depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00176473
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Linear epitope mapping of humoral responses induced by vaccination with recombinant HIV-1 envelope protein gp160 (1997)
    Springer
    Journal of industrial microbiology and biotechnology 19 (1997), S. 58-65 
    Details
    ISSN: 1476-5535
    Keywords: Keywords: HIV vaccines; HIV antibodies; gp120; gp41; Pepscan; statistical data analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: To enhance utility of the linear epitope mapping (Pepscan) technique for assay of humoral responses linked to vaccination, two modifications were tested. First, peptides were incubated with serum contained in baths rather than individual wells. Second, a rigorous statistical model was developed to determine which peptide/antibody-binding interactions were significant. The modifications increased the ability to detect signal in these experiments by 15- to 45-fold. These two modifications were applied to linear epitope mapping of HIV seropositive volunteers under treatment with recombinant HIV gp160 and also to rabbits immunized with the same product. Changes in fine specificity of response were observed in animal models and human vaccine recipients over the course of an immunization series with this antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/sj.jim.2900410
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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