ISSN:
1432-0878
Keywords:
Glia
;
Haemocyte
;
Central nervous system
;
Bleomycin
;
Neural repair
;
Insect, Periplaneta americana
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The DNA-binding drug, bleomycin, has a profound effect on neural repair following selective glial disruption by ethidium bromide. The contribution of the granule-containing cells (which normally appear in the early stages of repair) is greatly reduced, the restoration of the blood-brain barrier is delayed and the ultrastructural organization of the reorganising perineurium is dramatically changed. The aberrant perineurial structure and function observed in the presence of bleomycin are postulated to result from the effects of the drug on haemocytes which, together with endogenous reactive cells, contribute to the normal process of glial repair.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00251054
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