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  • 1
    Electronic Resource
    Electronic Resource
    C-reactive protein as an indicator of resolution of sepsis in the intensive care unit (1995)
    Springer
    Intensive care medicine 21 (1995), S. 602-605 
    Details
    ISSN: 1432-1238
    Keywords: Sepsis ; C-reactive protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To investigate the value of decreasing plasma C-reactive protein (CRP) concentrations as an indicator or resolution of microbiologically-proven sepsis.Design: Retrospective analysis of CRP concentrations measured during episodes of microbiologicallyproven sepsis. A receiver-operating characteristic (ROC) curve was used to assess the usefulness of CRP as a test for resolution of sepsis. Setting The intensive care unit (ICU) of a teaching hospital.Patients and participants: 32 episodes of microbiologically-proven sepsis occurring in 18 patients were followed from diagnosis until resolution. Measurements and results Daily routine observations and blood testing were performed prospectively. The daily presence or absence of systemic inflammatory response syndrome (SIRS) was prospectively determined according to standard definitions. Concentrations of CRP were analysed retrospectively once the patients had left the ICU. A decrease in CRP by 25% or more from the previous day's level was a good indicator of resolution of sepsis, with a sensitivity of 97%, specificity of 95% and predictive value of 97%. In 13 cases (46%), a decrease in CRP preceded clinical resolution of sepsis; this was more likely to occur in patients with less severe sepsis than in those with severe sepsis or septic shock. Conclusion Daily measurement of CRP is useful for monitoring the course of microbiologically-proven sepsis in ICU patients, and may be used to indicate successful treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01700168
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of low-dose dopamine infusions on haemodynamic and renal parameters in patients with septic shock requiring treatment with noradrenaline (1998)
    Springer
    Intensive care medicine 24 (1998), S. 564-568 
    Details
    ISSN: 1432-1238
    Keywords: Key words Dopamine ; Haemodynamic ; Renal ; Sepsis ; Shock ; Noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To investigate whether low-dose dopamine (LDD) has a significant effect on systemic haemodynamic variables and renal function when used in conjunction with high-dose noradrenaline in optimally volume-resuscitated patients with septic shock. Design: A prospective clinical study in which each patient acted as his/her own control. Setting: Teaching hospital Intensive Care Unit. Patients: Twenty-one patients with septic shock treated with high-dose noradrenaline were studied, 17 patients completed the study. Interventions: Fluid loading to an optimal left ventricular stroke work index (LVSWI) whilst on more noradrenaline than 10 mcg/min and dopamine of 2.5 mcg/kg per min. Three study periods each of 2 h with LDD present, withdrawn and restarted. During each period a complete haemodynamic profile and measurement of urine flow rate, creatinine clearance and sodium excretion was performed. Measurement and results: Removing and restarting LDD caused marked changes in cardiac index (CI, 17 % fall, p 〈 0.01: 23 % rise, p 〈 0.01), stroke volume (SV, 11 % fall, p 〈 0.05: 14 % rise, p 〈 0.05) and systolic blood pressure (SBP, 11 % fall, p 〈 0.05: 14 % rise, p 〈 0.05). Urine volume fell by 40 % (p 〈 0.05) when dopamine was withdrawn. Significant reductions in sodium excretion (p 〈 0.05) and fractional sodium excretion (p 〈 0.05) also occurred on stopping LLD. Changes in creatinine clearance were not statistically significant. Conclusion: Low-dose dopamine causes significant increases in SBP SV, cardiac output and urine flow during treatment with noradrenaline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050616
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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