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  • 1
    Electronic Resource
    Electronic Resource
    Central haemodynamics and regional blood flow during halothane-nitrous oxide anaesthesia and controlled ventilation (1983)
    Springer
    Research in experimental medicine 182 (1983), S. 193-201 
    Details
    ISSN: 1433-8580
    Keywords: Rat ; Halothane ; Anaesthesia ; Regional blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The haemodynamic effects of halothane-N2O/O2 anaesthesia with controlled ventilation were studied in rats, using the microsphere method. Mean arterial blood pressure was significantly reduced but only minor effects on cardiac output (CO), heart rate, and systemic vascular resistance were seen. During anaesthesia, there were significantly increased fractions of CO delivered to brain, lungs, small intestine and liver (hepatic artery), while the fractions to spleen, stomach and carcass were decreased. Fractional distribution and regional blood flow to heart, kidneys, adrenals and preportal area remained unchanged. When anaesthesia was prolonged from 60 to 90 min, no further changes in central or regional haemodynamics were seen. Considering the minor effects on central haemodynamics and the abscense of changes in central and regional haemodynamics at 60 and 90 min, this anaesthesia model should be useful in experimental research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851708
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bambuterol and terbutaline in human cerebrospinal fluid and plasma (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 147-150 
    Details
    ISSN: 1432-1041
    Keywords: Terbutaline ; Bambuterol ; Cerebrospinal fluid ; plasma ; human ; adverse effects®
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Concentrations in cerebrospinal fluid (CSF) and plasma of bambuterol and its active metabolite, the β2-adrenoceptor agonist terbutaline, were measured in man after four once-daily doses of 30 mg bambuterol hydrochloride (Bambec®). Nine patients scheduled for orthopaedic surgery under spinal anaesthesia completed the study. The concentrations of both substances were much lower in CSF than in plasma, the ratio CSF/plasma being 0.09 for bambuterol and 0.19 for terbutaline, at apparent steady state. While the rank order of the ratios was expected from the fractions of unbound bambuterol and terbutaline in plasma, their absolute values were only about 1/6 (bambuterol) and 1/4 (terbutaline) of those predicted from diffusion equilibria between plasma and CSF. Thus, the rates of transport of bambuterol and terbutaline from plasma into the central nervous system appear to be slow relative to transport out of the system, e.g. by outflow of CSF. The findings are in agreement with animal experiments and suggest that bambuterol and terbutaline are less likely than lipophilic β2-adrenoceptor agonists to interact with central receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315496
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    Paper (German National Licenses)
    Fulltext
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