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  • 1
    Digitale Medien
    Digitale Medien
    Precancerous conditions for pancreatic cancer (2000)
    Springer
    Journal of hepato-biliary-pancreatic surgery 7 (2000), S. 575-579 
    Details
    ISSN: 1436-0691
    Schlagwort(e): Key words Precancerous conditions ; Pancreatic duct adenocarcinoma ; Hamster ; Human
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Precancerous conditions for ductal adenocarcinoma of the pancreas in hamsters and human beings are discussed. In hamsters, ductal adenocarcinomas induced by nitrosamines are of nonmucin-hypersecreting tubular or papillary tumor types, and genetic alterations resembling these types are found in their human counterparts. Ductal lesions develop step-by-step from hyperplasias to carcinomas, and atypical ductal cell hyperplasias may be precancerous. In humans, ductal lesions, hyperplasias, or dysplasias, with or without mucin hypersecretion, are possible preneoplastic conditions. Genetic or phenotypic markers to determine their likelihood of progressing to pancreatic duct adenocarcinomas are a high priority for future research.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005340070006
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Ultrastructural lipid and glycoconjugate cytochemistry of membranous lipodystrophy (Nasu-Hakola disease) (1991)
    Springer
    Virchows Archiv 419 (1991), S. 137-142 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Membranous lipodystrophy ; Nasu-Hakola disease ; Lipid and glyconconjugate ; Cytochemistry ; Electron microscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to assess the lipid and glycoconjugate characteristics of membranous lipodystrophy, a 29-year-old male with this disease was studied using an ultrastructural cytochemical approach. The specific membranocystic lesions of the disease are composed of cystic spaces and the lining membranes. The membranes were observed to have a two-layered character: microtubular structures in the layer adjacent to the spaces and a central amorphous zone. Lipid staining and the lipase digestion test revealed triglycerides localized not only in the cystic spaces but also in the microtubular structures. Lectin histochemical examintion of carbohydrate components demonstrated thatMaclura pomifera agglutinin bound strongly to the membranes, whileGriffonia simplicifolia I,G. simplicifolia II,Concanavalia ensiformis andTriticum vulgaris agglutinin reacted weakly. Our results indicate the presence of triglycerides and carbohydrates with mainlyα-D-galactose residues in the distinctive membranocystic lesions, in particular in the microtubular structures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01600227
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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