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Regulation of hsp70 induction in thermotolerant HeLa cells

Hatayama, T. ; Asai, Y. ; Wakatsuki, T. ; [et al.]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1179 (1993), S. 109-116

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ISSN: 0167-4889

Keywords: Heat shock protein ; Heat shock transcription factor ; Thermotolerant cell

Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Topics: Biology , Chemistry and Pharmacology , Medicine , Physics

Type of Medium: Electronic Resource

URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4889(93)90131-8

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Role of thromboxane A2 in a microcirculation disorder of the rat inner ear (1993)

Umemura, K. ; Asai, Y. ; Uematsu, T. ; [et al.]

Springer

European archives of oto-rhino-laryngology and head & neck 250 (1993), S. 342-344

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ISSN: 1434-4726

Keywords: Hearing disorders ; Inner ear microcirculation ; Thromboxane A2 synthetase inhibitor ; Thromboxane A2 receptor antagonist disorder

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Since thromboxane (TX) A2 causes vasoconstriction and platelet aggregation, we evaluation the effect of a TXA2 receptor antagonist (vapiprost) and a TXAZ synthetase inhibitor (Y-20811) on a microcirculation disorder in the rat inner ear that was induced by a photochemical reaction between an intravenous injection of rose bengal (RB) and green light. A gradual decrease of the cochlear action potential (CAP) to an 8 kHz sound stimulus was measured with an electrocochleogram and occurred after the RB injection. The CAP then disappeared 5 min after the injection of RB. Both vapiprost and Y-20811 significantly prolonged the time required to complete suppression of the CAP as compared with saline as control. These findings indicate that TXAZ may play an important role in microcirculation disorders in the rat inner ear.