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  • 1
    Electronic Resource
    Electronic Resource
    Effect ofStrongyloides ratti on small bowel function in normal and immunosuppressed host rats (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 1316-1321 
    Details
    ISSN: 1573-2568
    Keywords: Strongyloides ; parasites ; absorption ; d-xylose ; sucrase ; lactase ; alkaline phosphatase ; immunosuppressed
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although Strongyloides stercoralis is a common parasite, little is known about its effect on intestinal function. Published clinical studies are difficult to evaluate and compare because of the inability to differentiate the effects of the parasite load from that of various other coexisting features such as bacterial overgrowth, multiparasitism, malnutrition, or tropical sprue. Using a rat model where these problems do not occur, we found that Strongyloides ratti did not inhibit intestinal function in the healthy rat. In fact, in normal rats S. ratti appeared to increase ileal sucrase activity. In contrast, in the methylprednisolone-treated rat, S. ratti produced a decrease in lactase and sucrase activity and an increase in alkaline phosphatase activity. S. ratti had no effect on 3-O-methylglucose uptake ord-xylose absorption in either group. These results suggest that S. ratti has little effect on small bowel function in a healthy rat but can cause minor alterations in intestinal function in an immunosuppressed, methylprednisolone-treated, malnourished host. These results are also consistent with clinical observations seen with S. stercoralis in humans and with another nematode, Ascaris suus, in the pig model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536685
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  • 2
    Electronic Resource
    Electronic Resource
    Determination ofHelicobacter pylori status by reverse transcription-polymerase chain reaction (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 109-113 
    Details
    ISSN: 1573-2568
    Keywords: Helicobacter pylori ; RT-PCR ; urea breath test ; polymerase chain reaction ; detection ; transmission ; epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We previously reported the development and the possible application of reverse transcription-polymerase chain reaction (RT-PCR) assay for the detection ofH. pylori in gastric mucosal biopsy specimens. In this communication, the application of this assay was assessed by comparing its results from 79 gastric biopsy specimens obtained from 68 patients with the more traditional [13C]urea breath test. When the amplified products were examined, the specificity and sensitivity of this RT-PCR assay were 100% and 47% on agarose gels and 80% and 91% by Southern hybridization, respectively. The specificity and sensitivity of urea breath test were 91% and 96% and were generally superior to RT-PCR (negative predictive value of 94% for UBT and 59–76% for RT-PCR). Although our RT-PCR results compare favorably with other PCR assays applied to gastric biopsy specimens for the detection ofH. pylori, the use of this method did not add significantly to currently available noninvasive diagnostic methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02063952
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    Paper (German National Licenses)
    Fulltext
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