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  • 1
    Electronic Resource
    Electronic Resource
    Benzodiazepines and behavioral effects of reward (water) omission in the rat (1978)
    Springer
    Psychopharmacology 59 (1978), S. 95-100 
    Details
    ISSN: 1432-2072
    Keywords: Frustrative nonreward ; Response suppression ; Over-responding ; Benzodiazepines ; Amobarbital ; Meprobamate ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two behaviors related to nonreward (omission of water in an enclosure where the rats were habituated to drink) were studied. The time spent licking the bottles during water omission and the time spent drinking during a subsequent 5-min drinking session (water available) were recorded. The drinking session was performed 30 min after the water-omission session. Rats subjected to water omission showed an enhanced drinking time that varied with the length of the water omission session, with the motivational state of the animals, and with the previous number of wateromission sessions. Diazepam, chlordiazepoxide, lorazepam, and meprobamate (i.p., 30 min before water omission), increased the time spent licking the empty bottles, but failed to abolish subsequently enhanced drinking. However, some of our data suggested that minor tranquilizers weakly reduced the increased drinking induced by nonreward, despite their direct stimulation on water drinking. It is proposed that either minor tranquilizers are devoid of general antifrustration activity or nonreward-induced frustration and nonreward-induced drive enhancement may not be correlated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428038
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effets des anxiolytiques sur la prise de nourriture de rats et de souris placés en situation nouvelle ou familière (1975)
    Springer
    Psychopharmacology 45 (1975), S. 203-210 
    Details
    ISSN: 1432-2072
    Keywords: Food intake ; Benzodiazepines ; Barbiturates ; Meprobamate ; Rats ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Various minor tranquilizers (benzodiazepines, barbiturates and meprobamate) induced an increase in the food intake of rats or mice. Drugs were injected i.p. 30 min before testing and the amount of food consumed during 30 min was recorded. The enhanced food consumption occurred when the animals were in a novel situation, in a situation which they had previously experienced, or in their home cage, in which they were used to eating in the daytime within 30 min. Studies with two benzodiazepines showed this effect to be maximal between 10 to 30 min after injection and to disappear 4 hrs after injection. Moreover, minor tranquilizers reduce the latency before eating of rats and mice tested in a new situation. These results and the observation of anti-anxiety drugs-induced hyperphagia in satiated animals suggest that: 1. The enhanced food consumption of a non familiar food in a novel situation induced by the minor tranquilizers could hardly be related only to their anti-anxiety action. 2. The existence of some inhibitory controls (endogenous satiety in daytime or satiety after recent absorption) is not essential for the action of the minor tranquilizers. 3. An increased motivation and a disruption in the food related behavior could possibly be an explanation for all the observed effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429062
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effets des anxiolytiques sur la prise de boisson en situation nouvelle et familière (1976)
    Springer
    Psychopharmacology 50 (1976), S. 41-45 
    Details
    ISSN: 1432-2072
    Keywords: Water intake ; Benzodiazepines ; Phenobarbital ; Meprobamate ; Mecloqualone ; Rats and mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In water-deprived rats and mice, animals trained to the test situation spent more time in drinking than naive animals (first exposure to the test situation). The time spent in drinking, either during 5 min or during 10 min was recorded. As compared to controls, benzodiazepines, phenobarbital, meprobamate, and mecloqualone increased drinking time whether the experiments were run on naive or on experienced animals [5 or 10 (in mice) and 9 (in rats) exposures in the test situation]. All drugs were injected i.p. 30 min before testing. This release of the drinking behavior was more pronounced during the last 5 min than during the first 5 min of the 10 min test session. These results suggest that: 1. The inhibition of water intake of naive animals as compared to trained rats and mice, could be related to some emotional factors elicited by the first exposure to an unknown situation. 2. The increase in drinking time induced by the antianxiety drugs in a novel and in a familiar situation seems difficult to correlate only with the antianxiety action of these compounds. 3. Antianxiety drugs could interfere with the regulatory mechanism of thirst.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634152
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    Paper (German National Licenses)
    Fulltext
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