ISSN:
1433-8580
Keywords:
Hepatic regeneration
;
Thymus alteration
;
Monoclonal antibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We performed 70% hepatectomy in LEW rats and examined immunologic alterations during hepatic regeneration; especially, thymus weight and cell count, T-cell subpopulations, differentiation ratio of thymocytes (DR) and ratio of T-helper to T-suppressor/cytotoxic cells (Th-Tsc). Strongest liver regeneration was observed on postoperative days 2–5 and it was completed on day 7. During hepatic regeneration a significant thymus atrophy in weight and cell count was found on day 3 and 5, it normalized from the 7th day on. T-cells were highly differentiated during liver regeneration with a DR of 35.7 ± 2.5%, 64.0 ± 4.4% and 38.8 ± 3.0% on postoperative days 3, 5, and 7, respectively, and at the same time Th-Tsc ratio was reduced to 0.57 ± 0.11, 0.38 ± 0.04 and 0.57 ± 0.05, respectively. DR and Th-Tsc ratio showed a trend to normalization from the 7th day on. No changes of thymus and T-cell subpopulations occurred in a sham-operated control group. Since we found such thymus alterations also in spontaneous or drug induced tolerant graft recipients, we conclude that the hepatic regenerative potential possesses a suppressive effect on immune responses.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01855664
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