ISSN:
1432-1076
Keywords:
Fanconi anaemia
;
Androgens
;
Hepatic tumour
;
Hepatic adenoma
;
Peliosis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The occurrence of liver tumours in the course of Fanconi anaemia (FA) has been well documented. We present a case, review the literature and conclude that androgen therapy would increase the risk of developing tumours, most of which appear to be benign (adenomas or peliosis) and androgen-dependent, generally decreasing in size after cessation of treatment. Survival of patients is poor, mostly because of the rapid evolution of untreated FA, rather than rupture or degencration of the tumour. In the absence of an allogenic bone marrow transplantation, administration of haematopoietic growth factors might be effective. As a preventive measure, other types of unsubstituted androgens may be used.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01955250
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