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  • 1
    Electronic Resource
    Electronic Resource
    C1q-bearing immune complexes detected by a monoclonal antibody to human C1q in rheumatoid arthritis sera and synovial fluids (1991)
    Springer
    Rheumatology international 10 (1991), S. 245-250 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis sera/synovial fluids ; Immune complexes ; C1q-bearing immune complexes ; Monoclonal anti-C1q antibody
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a monoclonal antibody directed against the C-chain of human C1q, we detected C1q-bearing immune complexes (IC) in sera and synovial fluids of rheumatoid arthritis (RA) patients. In a sandwich-ELISA, C1q-bearing IC were captured by the solid-phase monoclonal antibody and then detected with peroxidase-labeled F(ab′)2-antibodies to either human IgG or IgM. The results of this assay were compared to an ELISA-modification of the C1q-solid-phase binding assay (C1q-SPBA). C1q-bearing IC were detected in 81.1% of RA-sera and the 65.2% of RA-synovial fluids. IgG as well as IgM was present in 72.6% of the sera and 70% of the synovial fluids which were positive in both assays. Most RA sera that were only positive for C1q-bearing IC, contained IgG alone (81.5%). The corresponding synovial fluids showed IgG alone (53%) or both IgG and IgM (41.1%). IgM alone (25%) could be detected in sera, e.g. in juvenile forms of RA. The levels of IC were higher in synovial fluid than in paired serum. In comparison to normal human serum (NHS) and patients with osteoarthritis, complement activity (CH50 titers) and C1q-values in patients with RA were frequently elevated. Since the formation of C1q-bearing IC is an indicator for the classical complement pathway activation, an assay with monoclonal anti-C1q antibody may be a useful tool in the diagnosis of rheumatoid diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274887
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  • 2
    Electronic Resource
    Electronic Resource
    Possible therapy in hereditary angioneurotic edema (HAE) (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 620-622 
    Details
    ISSN: 1432-1440
    Keywords: Hereditary angioneurotic edema ; tranexamic acid ; suramin ; C $$\bar 1$$ -inhibitor ; Hereditäres angioneurotisches Ödem ; Tranexamsäure ; Suramin ; C $$\bar 1$$ -Inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die symptomatische Therapie des hereditären angioneurotischen Ödems mit Tranexamsäure und Suramin bei zwei Patienten berichtet. Während der erste Patient gut auf eine Therapie mit Tranexamsäure (Cyclocapron®), nicht jedoch auf Suramin ansprach, ließen sich beim zweiten Patienten die Ödemanfälle mit Suramin unterbinden.
    Notes: Summary The symptomatic therapy of hereditary angioneurotic edema with tranexamic acid and suramin in two patients is reported. The first patient responded well to tranexamic acid (Cyclocapron®) but not to suramin. In the second patient, attacks of edema could apparently be better prevented with suramin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468576
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    Paper (German National Licenses)
    Fulltext
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