ISSN:
0570-0833
Keywords:
Conformation analysis
;
Heterocycles
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
This review deals with the following aspects of conformational analysis in saturated heterocyclic systems: 1. Conformational equilibria in 2-aryl and 2-ethynyl-1,3-dioxanes in various solvents. 2. The generalized anomeric effect in perhydro-1,3-diazines and its origin. 3. Unexpected conformational equilibria in 5-heterosubstituted 1,3-dioxanes. 4. Normal and anomalous solvent effects in conformational equilibria of 1,3-dioxanes with heteroatoms at C-5. Calculation of solvent effects. Correlation of ΔG0 as a function of solvent with solvatochromic transition energy ET (30); a new scale of “solvent polarity”. 5. Interplay of hydrogen bonding with dipolar, non-bonded and eclipsing interactions in 5-hydroxymethyl- 1,3-dioxanes. 6. Highly stereoselective H-D exchanges in anancomeric 1,3-dithianes. 7. Potential distortion of a cyclohexane or 1,3-dioxane ring by a tert-butyl substituent. Evidence from 1H-NMR and 13C-NMR investigations and from X-ray structure analysis.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.197207391
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