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  • 1
    Electronic Resource
    Electronic Resource
    Influence of chloroquine on the porphyrin metabolism (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 114-117 
    Details
    ISSN: 1432-069X
    Keywords: Hepatic porphyria ; Chloroquine ; Hexachlorobenzene ; δ-Aminolevulinate synthase ; Cytochrome P-450
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats were treated with the well-known porphyrogen hexachlorobenzene (HCB) to induce experimental porphyria. At the same time another group of rats was treated with chloroquine in addition to HCB. The HCB-induced increase of the urinary excretion of porphyrin precursors could thereby be reduced to normal levels and the porphyrin excretion rates were decreased significantly in comparison to those of the other group. The δ-aminolevulinate synthase in the liver of the animals was slightly increased by exclusive treatment with chloroquine, which in the HCB-treated rats chloroquine led to a dramatic decrease in the key enzyme of the porphyrin (heme)-biosynthesis. The influence of chloroquine on the HCB-induced increase of the cytochrome P-450 content and the dependent enzymatic activities were different. The 7-ethoxycumarin deethylase and the arylhydrocarbon hydroxylase activities were not influenced, whereas the increased aminopyrine-N-demethylase activity was reduced to nearly normal levels. Our findings indicate that chloroquine acts by reduction of the δ-aminolevulinate synthase activity, probably by influencing the regulation of the key enzyme of the heme biosynthesis, which is enhanced in human porphyria cutanea tarda, as well as in the HCB-induced porphyria of the rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414107
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of oral thalidomide on rat liver and skin microsomal P450 isozyme activities and on urinary porphyrin excretion: interaction with oral hexachlorobenzene (1994)
    Springer
    Archives of dermatological research 286 (1994), S. 347-349 
    Details
    ISSN: 1432-069X
    Keywords: Thalidomide ; Liver ; Skin ; Cytochrome P450 ; Porphyrins ; Hexachlorobenzene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adult female Wistar rats (n=48) divided into four groups of 12 were treated orally with 3 mg/kg per day thalidomide, a 0.05% hexachlorobenzene (HCB) — containing diet, with both drugs together and with the vehicles (controls) over periods of 10 and 60 days. The protein and P450 contents and the activities of amino-pyrine-N-demethylase (ADM) and 7-ethoxyresorufine-O-deethylase (7-ERO-D) were determined in the liver microsomes. The activity of 7-ERO-D was also determined in the skin microsomes and total porphyrins were measured in the urine of the animals. Thalidomide increased the hepatic P450 content, caused distinct changes in the activities of the hepatic and cutaneous microsomal isozymes, modified their induction by HCB and inhibited the porphyriogenic activity of HCB. These findings indicate an interaction between thalidomide and HCB with regard to their effects on the P450 isozymes and the metabolism of porphyrins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402227
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of hexachlorobenzene on enzymes of the steroid metabolism in rat liver (1979)
    Springer
    Archives of toxicology 43 (1979), S. 115-120 
    Details
    ISSN: 1432-0738
    Keywords: Hexachlorobenzene ; Steroid-5α-reductase ; 3-hydroxysteroid dehydrogenases ; Porphyria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Erwachsene weibliche Wistar-Ratten wurden mit 0.05% Hexachlorbenzol enthaltendem Futter ernährt. Am 60. Tag dieser Behandlung waren die spezifischen Aktivitäten der NADPH: Δ 4-3-oxosteroid-5α-Reduktase und der 3-Hydroxysteroid-Dehydrogenasen in Lebermikrosomen, verglichen mit Kontroll-Ratten, vermindert. Die cytoplasmatische 5β-Reduktion war bei HCB-behandelten Ratten höher als bei Kontroll-Ratten. Diese Veränderungen des Steroidmetabolismus führen zu vermehrter Bildung von 5β-H-Steroiden, von denen bekannt ist, daß sie Induktoren der Porphyrin-Biosynthese sind.
    Notes: Abstract Adult female Wistar rats were fed with a diet containing 0.05% hexachlorobenzene. On the 60th day of this treatment the specific activities of NADPH: Δ 4-3-oxosteroid-5α-reductase and the 3-hydroxysteroid dehydrogenases in rat liver microsomes were diminished compared to control rats. The cytoplasmatic 5β-reduction was higher in HCB treated rats than in control rats. These alterations of the steroid metabolism lead to increased formation of 5β-H-steroids which are known to be inducers of the porphyrin biosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333618
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    Paper (German National Licenses)
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