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Influence of experimental diets on hepatic glutathione levels in rats with methylnitrosourea-induced mammary carcinoma (1985)

Aksoy, M. ; Frei, E. ; Berger, M. R.

Springer

Journal of cancer research and clinical oncology 110 (1985), S. 244-246

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ISSN: 1432-1335

Keywords: High fat diet ; Vitamin A ; Vitamin E ; Reduced glutathione

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Mammary tumor development induced by methylnitrosourea in female Sprague-Dawley rats had no significant effect on hepatic glutathione levels. If the diets of methylnitrosourea-treated animals were supplemented with vitamin A and E an increased hepatic glutathione level was observed initially. A high fat diet (21% per weight) supplemented with the two vitamins led to a decreased hepatic glutathione level 2 months after tumor induction. Advanced tumor development under any of the diets tested had no effect on hepatic glutathione.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00399282

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