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  • High resolution nuclear magnetic resonance imaging  (1)
  • Microtubule-associated protein-2  (1)
  • Spinal cord  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Specific monoclonal antibodies against normal microtubule-associated protein-2 (MAP2) epitopes present in Alzheimer pathological structures do not recognize paired helical filaments (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 179-189 
    Details
    ISSN: 1432-0533
    Keywords: Microtubule-associated protein-2 ; Somatodendritic distribution ; Alzheimer's disease ; Senile plaque neurites ; Paired helical filaments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have developed monoclonal antibodies that detect normal microtubule-associated protein-2 (MAP2) epitopes in routinely fixed, paraffin-embedded tissue. The somatodendritic distribution of MAP2 in bovine and human nervous tissue was confirmed with several of these antibodies. Furthermore, some of these antibodies immunohistochemically labeled certain pathological structures in Alzheimer brain, especially neurites in senile plaques. Electron microscopic observations, however, indicate that these MAP2 epitopes are not located in the Alzheimer paired helical filaments themselves, but in amorphous granular structures coexistent with them. While the pathological nature of these structures is undetermined, they may represent artefactual modifications of normal cytoskeletal components.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308477
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    High resolution nuclear magnetic resonance imaging of the spinal cord in experimental demyelinating disease (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 628-632 
    Details
    ISSN: 1432-0533
    Keywords: Chronic experimental allergic encephalomyelitis ; Spinal cord ; High resolution nuclear magnetic resonance imaging ; Demyelination ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronic recurrent experimental allergic encephalomyelitis was induced in a strain 13 guinea pig by inoculation of isologous spinal cord homogenate. The spinal cord was obtained after perfusion with 4% paraformaldehyde and examined with nuclear magnetic resonance (NMR) imaging. Proton NMR spin echo images (repetition time: 3 s; echo times: 20 and 60 ms) were obtained from intact, isolated spinal cord in a 4.7 Tesla, 50 mm bore magnet. The slice thickness of the images was 380 μm and the inplane resolution was 40×40 μm. The images showed superficial areas of low signal intensity in the lateroventral regions of the white matter, in some instances with a seam of higher signal intensity. Neuropathologically, these abnormalities corresponded exactly to areas of demyelination. Control images did not show these abnormalities. The present high resolution imaging allowed a correlation between demyelination and abnormal NMR signals in a small laboratory animal with an inflammatory demyelinating disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689603
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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