Electronic Resource
Springer
Journal of molecular medicine
71 (1993), S. 161-164
ISSN:
1432-1440
Keywords:
Allopurinol
;
Breast milk
;
High-pressure liquid chromatography
;
Oxypurinol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To pregnant or breast feeding women drugs should be given with caution. We report the case of a 5-week-old breast-fed infant whose mother was taking 300 mg allopurinol/day for 4 weeks. Allopurinol and oxypurinol were detected by HPLC in maternal plasma and breast milk with a method first described here. In infant's plasma taken 2 h after breast feeding oxypurinol was found; allopurinol was below the limit of detection. The milk/plasma ratio in the mother 2 h (4 h) after drug ingestion was 0.9 (1.4) for allopurinol and 3.9 (2.4) for oxypurinol. The average daily dose for the baby of allopurinol was 0.14–0.20 mg/kg and that of oxypurinol 7.2–8.0 mg/kg by ingestion of breast milk after oral intake of allopurinol by the mother.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00179999
Permalink
| Library |
Location |
Call Number |
Volume/Issue/Year |
Availability |
