Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Anxiogenic-like effect of infusing 1-(3-chlorophenyl) piperazine (mCPP) into the hippocampus (1990)
    Springer
    Psychopharmacology 101 (1990), S. 138-140 
    Details
    ISSN: 1432-2072
    Keywords: Anxiety ; 1-(3-Chlorophenyl)piperazine (mCPP) ; Hippocampus ; 5-HT1C receptor ; Social activity ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT1C receptors with an ED50 of approximately 500 µg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 µg of the drug ICV or infusing 0.5 µg into the hippocampus. Both responses were dose dependent. Infusion of 1 µg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245806
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT (1990)
    Springer
    Journal of neural transmission 79 (1990), S. 93-101 
    Details
    ISSN: 1435-1463
    Keywords: Hippocampus ; 5-hydroxytryptamine ; 5-HT1A receptors ; sex differences ; spatial learning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Brain regional 5-hydroxytryptamine (5-HT) and/or 5-hydroxyindoleacetic acid (5-HIAA) concentrations tended to be slightly higher in female rats than in males but differences were substantial only in the hippocampus where female values were 34% and 36% higher respectively. These findings were consistent with the synthesis rates of 5-HT as this was 53% greater in the female than in the male hippocampi. Other regions did not show significant sex differences. The 5-HT[n1A] agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT, 1 mg/kg sc) caused comparable decreases of 5-HT synthesis rate in both sexes and in all regions studied except the hippocampus where the percentage decrease was twice as large in the females (−64%) as in the males (−32%) so that the sex difference in 5-HT synthesis in this region largely disappeared. The results are discussed in relation to sex differences in behaviour and hippocampal function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01251004
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...