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  • 1
    ISSN: 1432-1912
    Keywords: Respiratory Center ; Brain Stem ; Reticular Formation ; Respiratory Neuron ; Unitary Discharge ; Respiratorisches Zentrum ; Hirnstamm ; retikuläre Formation ; respiratorisches Neuron ; Einzelzellentladung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden die Lokalisation und das Aktivitätsmuster respiratorischer Einheiten in der Substantia reticularis bulbi et pontis an Pentobarbital-narkotisierten, spontan atmenden und an Gallamin-immobilisierten, künstlich beatmeten Katzen unter Lokalanaesthesie untersucht. 1. An beiden Präparationen waren in der Substantia reticularis bulbi die respiratorischen Einheiten diffus verteilt und untereinander gemischt. 2. In der Substantia reticularis pontis ließen sich zahlreiche respiratorische Einheiten an der immobilisierten und vagotomierten Katze, jedoch nicht am narkotisierten Tier ableiten. 3. Exspiratorische und zwei Typen von „phase-spanning“-Einheiten wurden wesentlich häufiger in der Medulla immobilisierter Katzen als bei narkotisierten Katzen gefunden. 4. Der Vergleich der Aktivitätsmuster von Einheiten immobilisierter und narkotisierter Katzen zeigte, daß das Entladungsmuster der respiratorischen Einheiten durch diese unterschiedlichen Versuchsbedingungen weitgehend beeinflußt werden kann. Die Verteilung respiratorischer Einheiten in der Substantia reticularis der Medulla und des Pons sowie die Zusammenhänge zwischen Funktion und spontanem Entladungsmuster respiratorischer Neurone werden besonders im Hinblick auf die Lokalisation des „Atemzentrums“ diskutiert.
    Notes: Summary Localization and discharge pattern of respiratory neurons in the pontine and the medullary reticular formation were studied in both pentobarbital anesthetized cats and in cats immobilized with Flaxedil. 1. In both preparations inspiratory, expiratory and another broader group of neurons not so clearly related to respiratory phases were scattered and intermingled throughout the medullary reticular formation. 2. Respiratory neurons in the pontine reticular formation were detected in vagotomized and immobilized cats but not in cats under pentobarbital anesthesia. 3. Expiratory neurons and another broader group of respiratory neurons were found more frequently in immobilized cats than in anesthetized cats. 4. Comparisons of discharge patterns of respiratory neurons in both preparations indicated that the activity patterns of neurons were influenced by the experimental conditions. Localization of respiratory neurons in the medulla and the pons in relation to the localization of respiratory centers are discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 416 (1990), S. 375-384 
    ISSN: 1432-2013
    Keywords: Respiratory neurons ; Membrane potential ; Postsynaptic potentials ; Input resistance ; Halothane ; Thiopental ; Control of breathing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of two anesthetic agents, halothane and thiopental, on the membrane potential trajectory of respiratory-related neurons in the ventral respiratory group were investigated in decerebrate cats, of which the carotid sinus and vagal afferents were denervated. Infusion of halothane (2% for 90 s) depolarized the membrane in nearly half of the inspiratory (12/21), post-inspiratory (10/26) and expiratory (4/6) neurons and caused hyperpolarization in the rest of the population. Thiopental (2.5 mg/kg i.v.) produced depolarization in 11 inspiratory and 10 post-inspiratory neurons and hyperpolarization in 1 expiratory, 4 inspiratory and 7 postinspiratory neurons. In both hyperpolarized and depolarized neurons, reduction of the respiratory membrane potential fluctuations and an increase of input resistance were commonly observed. Both drugs depressed spontaneous firing in most of the neurons studied. An increase of firing was observed in 9 out of 47 depolarized cells. These two contrasting effects on the membrane potential trajectory occurred similarly in the known groups of respiratory neurons, but the response of a given cell was consistent for the two anesthetic agents. The present results demonstrate that the anesthetic drugs exert various influences on the ventral respiratory group neuron population in maintaining the membrane potential trajectory and discharge activity. This may reflect a functional heterogeneity in the bulbar respiratory network of neurons.
    Type of Medium: Electronic Resource
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