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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis of water-soluble (tri(hydroxymethyl)phosphine)gold(I) complexes containing a nucleoside ligand
    Amsterdam : Elsevier
    Inorganica Chimica Acta 217 (1994), S. 201-202 
    Details
    ISSN: 0020-1693
    Keywords: Gold complexes ; Nucleoside complexes ; Phosphine complexes
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-1693(93)03756-Z
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Histamine-stimulated production of matrix metalloproteinase 1 by human rheumatoid synovial fibroblasts is mediated by histamine H1-receptors (1995)
    Springer
    Virchows Archiv 427 (1995), S. 437-444 
    Details
    ISSN: 1432-2307
    Keywords: Histamine H1-receptor ; Matrix metalloproteinase-1 ; Phosphoinositol metabolism ; Intracellular calcium ; Rheumatoid synovial fibroblasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to investigate the role of histamine in human rheumatoid synovial fibroblasts in the production of factors responsible for tissue remodelling and cartilage breakdown in rheumatoid arthritis. We examined the effects of histamine of tritiated thymidine incorporation, production of matrix metalloproteinase-1 (MMP-1), histamine H1-receptor expression, phosphoinositide metabolism and intracellular calcium ion concentration ([Ca2+] i ) in human rheumatoid synovial fibroblasts. Tritiated thymidine incorporation studies demonstrated that histamine markedly stimulated the proliferation of rheumatoid synovial fibroblasts. Immunofluorescence and Northern blot analyses revealed that proMMP-1 production was also stimulated by histamine. The levels of inositol phosphates and [Ca2+] i in the cells were elevated in response to histamine, indicating that the cells expressed histamine H1-receptors; and Northern blot analysis indicated that these H1-receptors were up-regulated by histamine. In in situ hybridization, large amounts of histamine H1-receptor mRNA were also detected in rheumatoid synovial tissue. These results suggest that the interaction between H1-receptor expression in rheumatoid synovial fibroblasts and histamine secretion by mast cells and macrophages in the affected sites is an important event responsible for tissue remodelling and joint destruction in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199394
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Target sites of polymyxin B ototoxicity (1990)
    Springer
    European archives of oto-rhino-laryngology and head & neck 247 (1990), S. 129-130 
    Details
    ISSN: 1434-4726
    Keywords: Ototoxicity ; Polymyxin B ; Target sites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study was undertaken to determine the target sites of polymyxin B ototoxicity. This drug, at the concentration of 1 mM, was perfused through the scala tympani of the guinea pig cochlea, and cochlear microphonics and endocochlear potentials were monitored. Both cochlear potentials altered but in an independent manner. These findings indicated that not only the organ of Corti but also another tissue is involved in the ototoxicity produced. The best locus for this is the vascular stria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183184
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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