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  • 1
    Electronic Resource
    Electronic Resource
    Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease (1994)
    Springer
    Acta neuropathologica 87 (1994), S. 343-348 
    Details
    ISSN: 1432-0533
    Keywords: Parkinson's disease ; Substantia nigra ; Insulin receptor ; Immunochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunohistochemistry using both a newly developed polyclonal, and a commercially available monoclonal, anti-insulin receptor antibody was done on the midbrain from cases of idiopathic Parkinson's disease (PD), Alzheimer's disease, amyotrophic lateral sclerosis, vascular parkinsonism and non-neurological controls. Both antibodies gave indentical patterns of neuronal staining. The neurons of the oculomotor nucleus were immunopositive in all the brains. However, the neurons in the pars compacta of the substantia nigra, paranigral nucleus, parabrachial pigmental nucleus, tegmental pedunculopontine nucleus, supratrocheal nucleus, cuneiform nucleus, subcuneiform nucleus and lemniscus medialis, which were positive in other diseases and in non-neurological controls, were not stained by these antibodies in PD brains. These results suggest that, in PD, a dysfunction of the insulin/insulin receptor system may precede death of the dopaminergic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313602
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Senile plaques, amyloid β-protein, and acetylcholinesterase fibres: laminar distributions in Alzheimer's disease striate cortex (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 292-299 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; Visual cortex ; Amyloid ; Acetylcholinesterase ; Histopathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The laminar distributions of senile plaques and amyloid β-protein (AβP) within the striate cortex of patients with Alzheimer's disease (AD) were studied with enhanced Bielschowsky (roughly equivalent to the Campbell technique) and immunohistochemical methods. The laminar distribution of acetylcholinesterase (AChE) fibres within the striate cortex of both AD patients and control patients was studied with an enzyme histochemical method. Quantification of Bielschowsky-stained plaque numbers along intersect lines drawn parallel to laminar boundaries revealed a significant aggregation of plaques at the interface of layers IVc and V. Lines drawn through layer VI intersected significantly fewer plaques than lines through other laminae. Immunoperoxidase staining for AβP revealed a similar distribution fo senile plaques, and additional, prominent, diffuse deposits of AβP within layers I and IVc. AChE fibres were markedly depleted in the striate cortex of AD cases. In control cases, AChE fibres were, like AβP immunoreactivity, concentrated within layers I and IVc. The results indicate that enhanced silver methods may not reveal the complete distribution of AβP. The codistribution of AβP-immunoreactive diffuse amyloid deposits and AChE fibres to the same cortical laminae is consistent with the possibility that these deposits may be formed from degenerating cholinergic elements. The formation of a line of senile plaques at the interface of two cortical laminae within the striate cortex, in an anatomically analogous situation to a similar line of plaques within the dentate gyrus, suggests that formation of well-defined plaques may be accelerated by the interaction of specific neuronal systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296792
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lewy bodies in Parkinson's disease are recognized by antibodies to complement proteins (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 100-104 
    Details
    ISSN: 1432-0533
    Keywords: Parkinson's disease ; Complement ; Lewy bodies ; Oligodendrocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The substantia nigra (SN) in 11 Parkinson's disease (PD) patients and 5 neurologically normal controls was examined immunohistochemically using antibodies to various proteins of the complement system. In PD, but not in control SN, intra-and extraneuronal Lewy bodies and dendritic spheroid bodies were stained with anti-human C3d, C4d, C7 and C9 antibodies, but not with antibodies to C1q, fraction Bb of factor B or properdin. Axonal spheroid bodies in the nigrostriatal tract were not stained by any of the complement antibodies. However, complement-activated oligodendroglia were revealed by anti-C3d and anti-C4d antibodies in the PD substantia nigral area. These data indicate that some pathological structures in PD activate the classical complement pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427222
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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