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  • analytic methods  (2)
  • Human cerebellum  (1)
  • integral experiments  (1)
  • neutron activation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological comparison of the sigma recognition site labelled by [3H]haloperidol in human and rat cerebellum (1992)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 345 (1992), S. 197-202 
    Details
    ISSN: 1432-1912
    Keywords: Sigma recognition sites ; Human cerebellum ; Rat cerebellum ; [3H]haloperidol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The radioligand binding characteristics of [3H]haloperidol (in the presence of spiperone, 25 nmolL−1) were investigated in rat and human cerebellar membranes. In both rat and human cerebellar membrane preparations saturation studies with [3H]haloperidol (non-specific binding defined by pentazocine, 10 μmolL−1) demonstrated high affinity saturable specific binding to a homogenous population of binding sites (rat, Bmax 6693 ± 1242 fmol mg−1 protein, pKD 8.33 ± 0.08; human, Bmax 2550 ± 437 fmol mg−1 protein, pKD 8.59 ± 0.11; mean ± SEM, n = 3–6). Competition studies employing a wide range of structurally diverse competing compounds displayed that the [3H]haloperidol binding site was pharmacologically similar in both preparations and comparable to sigma recognition sites previously identified in various tissues originating from different species. In addition, with reference to the potential subtypes of sigma recognition sites, the labelling of these sites by low nanomolar concentrations of [3H]haloperidol provides evidence that they belong to the sigma-1 recognition site subtype. The present findings suggest that the pharmacology of the rat and human cerebellar sigma recognition site are directly comparable and provides further supporting evidence towards the use of [3H]haloperidol radioligand binding studies in the rat to detect sigma receptor ligands with potential therapeutic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165736
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Calculation of neutron and gamma-ray energy spectra for fusion reactor shield design: Comparison with experiment-II (1982)
    Springer
    Journal of fusion energy 2 (1982), S. 237-249 
    Details
    ISSN: 1572-9591
    Keywords: integral experiment ; neutron spectra ; gamma-ray spectra ; analytic methods
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Measured and calculated neutron and gamma-ray energy spectra resulting from the transport of ∼14 MeV neutrons through a 0.30-m-thick lithium hydride slab and through a 0.05-m-thick lead slab followed by 0.30 m of lithium hydride are compared. Also reported are comparisons of the measured and calculated neutron energy spectra behind an 0.80-m-thick assembly comprised of stainless steel type 304 and borated polyethylene. The spatial dependence of the gamma-ray energy deposition rate measured using thermoluminescent detectors is compared with calculated data. The calculated data obtained using two-dimensional radiation transport methods and ENDF/B-IV cross-section data are in good agreement for all of the experimental configurations. Calculated integral neutron energy spectra agree with the measured data within ∼5 to ∼20% depending on neutron energy for the LiH and Pb plus LiH assemblies. The gamma-ray spectra agree within 20% for these slabs. The measured and calculated neutron energy spectra behind the SS-304-borated polyethylene assembly agree within ∼5% except at neutron energies below ∼5 MeV where background radiation influences the measured spectra. The gamma-ray energy deposition rates as a function of depth agree within a factor of two at all detector locations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01050934
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of measured and calculated neutron and gamma ray energy spectra behind an in-line shielded duct (1982)
    Springer
    Journal of fusion energy 2 (1982), S. 403-412 
    Details
    ISSN: 1572-9591
    Keywords: integral experiments ; neutron spectra ; gamma-ray spectra ; analytic methods ; radiation streaming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Integral experiments that measure the transport of ∼ 14 MeV neutrons through a 0.30-m-diameter duct having a length-to-diameter ratio of 2.83 that is partially plugged with a 0.15 m diameter, 0.51 m long shield comprised of alternating layers of stainless steel type 304 and borated polyethylene have been carried out at the Oak Ridge National Laboratory. Measured and calculated neutron and gamma ray energy spectra are compared at several locations relative to the mouth of the duct. The measured spectra were obtained using an NE-213 liquid scintillator detector with pulse shape discrimination methods used to simultaneously resolve neutron and gamma ray events. The calculated spectra were obtained using a computer code network that incorporates two radiation transport methods: discrete ordinates (with P3 multigroup cross sections) and Monte Carlo (with continuous point cross sections). The two radiation transport methods are required to account for neutrons that singly scatter from the duct to the detectors. The calculated and measured neutron energy spectra above 850 keV agree within 5–50% depending on detector location and neutron energy. The calculated and measured gamma ray energy spectra above 750 keV are also in favorable agreement, ∼ 5–50%, depending on detector location and gamma ray energy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01053134
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Dose rates from the induced activity in the ETF neutral beam injector (1982)
    Springer
    Journal of fusion energy 2 (1982), S. 173-178 
    Details
    ISSN: 1572-9591
    Keywords: neutron activation ; neutral beam injectors ; fusion reactors ; doses rates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The dose equivalent rates outside the Engineering Test Facility neutral beam injector shield from the induced radioactivity have been calculated for the reactor operating at 1140 MW for 1, 30, and 365 days. The dose rates at one day after shutdown are large even after one day of operation. Depending on the location and operating time, cooling times from 30 days to ∼ 5 years are required before the dose rates are sufficiently low to allow routine maintenance work in the vicinity of the NBI shield.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01054583
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    Paper (German National Licenses)
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