ISSN:
1432-0533
Keywords:
Normal pressure hydrocephalus
;
Human cerebral cortex
;
Ultrastructure
;
Extracellular space
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A cortical biopsy was taken at the time when ventricular pressure was measured, or a ventriculo-atrial shunt placed, in 11 patients with Normal Pressure Hyprocephalus (N.P.H.), and was studied with the electron microscope. In 9 cases, a rather typical electron microscopic picture with marked increase of extracellular space in an otherwise normal cortical neuropil was observed. 2 patients did not exhibit this pattern and, coincendentally, did not benefit from the placing of the shunt. As a control, about 600 cortical biopsies that had been taken for other reasons were reviewed. In the group, there were only 3 cortices that had a pattern of increased extracellular space similar to the described in N.P.H. On review of the clinico-pathologic data of these cases, it was felt that all 3 probably represented cases of normal pressure hydrocephalus. It is concluded that the ultrastructure of the cerebral cortex is of at least nosological interest in the study of N.P.H.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00696564
Permalink
