ISSN:
1434-4726
Keywords:
Human papillomavirus
;
Head and neck cancer
;
Polymerase chain reaction
;
Southern blot hybridization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Cancer-free tissues from various anatomical subsites in the head and neck were examined by the polymerase chain reaction (PCR) for the incidence of human papillomavirus (HPV) types 16 and 18. We detected HPV 16 DNA in 9 of 103 samples (8.7%), including specimens from the paranasal sinuses, tonsil, hypopharynx and larynx. However, no HPV-16/18 DNA was detected by Southern hybridization in these 9 samples. The significance of the presence of HPV 16 DNA in non-cancer tissues is still unknown, but PCR detection only of high-risk HPV DNA in head and neck cancer should be evaluated cautiously because of its ubiquity in this region.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00179903
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