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Correlation of electron microscopic and secretory response of human parathyroid adenomas with different calcium concentrations in organ culture (1978)

Dietel, M. ; AltenÄhr, E. ; Montz, R. ; [et al.]

Springer

Virchows Archiv 378 (1978), S. 229-246

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ISSN: 1432-2307

Keywords: Human parathyroid adenomas ; Electron microscopy ; Parathyroid hormone release ; PTH radioimmunoassay ; Pathophysiology of primary hyperparathyroidism

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Twelve parathyroid chief cell adenomas from patients with primary hyperparathyroidism were incubated in a tissue culture system in the presence of different calcium concentrations and for various time periods. The endocrine response of the tissue was examined electron microscopically and radioimmunologically. After incubation in a medium of low calcium concentration the parathyroid adenomas showed ultrastructural signs of stimulation with proliferation of the hormone-synthesizing organelles. The development of the ultrastructural response could first be observed after four hours and increased up to several days. Radioimmunologically, an increase of the hormone secretion could be demonstrated. Converse results were obtained after incubation of the tumor tissue under suppressive culture conditions. To check for de-novo synthesis of the hormone released the tissue was incubated in a 75Se-methionine-containing medium. This resulted in radioactivity of the secreted parathyroid hormone, indicating de novo synthesis in our culture system. The biological potency of the released hormone was demonstrated by comparison of the PTH out of the medium with the international human MRC standard using two different radioassays.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00427362

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Untersuchungen zur Initiierung interkristalliner Schwingungsrisse in interstitiell freien (IF-) Stählen (1997)

Kocik, R. ; Pries, H. ; Finke, M. ; [et al.]

Weinheim : Wiley-Blackwell

Materialwissenschaft und Werkstofftechnik 28 (1997), S. 287-292

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ISSN: 0933-5137

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Description / Table of Contents: Investigations of initiation of intercrystalline fatigue cracks of interstitial free (IF-) steelsWhile investigation the fatigue strength of interstitial free steels, intercrystalline fatigue cracks have occurred as a damage which could reduce the application range of this material, being wellknown for its excellent depth drawing features. Through metallographic examination the known causes of the damage like formation of grain cover tertiary zementit of precipitations on the grain boundaries could be excluded. In this paper investigation results are represented which are received through high-resolution analyses techniques (TEM, AES).

Notes: Bei Untersuchungen zur Ermüdungsfestigkeit interstitiell freier Stähle sind mit dem Auftreten interkristalliner Schwingungsrisse erstmals Schadensmechanismen aufgetreten, die den Einsatzbereich dieses für seine hervorragenden mechanischen Eigenschaften bekannten Werkstoffes erheblich begrenzen können. In metallographischen Untersuchungen konnten die für dieses Schadensbild bekannten Ursachen wie die Bildung von schalenförmigem Tertiärzementit oder die Schwächung der Korngrenzen durch Ausscheidungen ausgeschlossen werden. Im vorliegenden Beitrag werden Untersuchungsergebnisse mit hochauflösenden elektronenoptischen Analyseverfahren (TEN, AES) vorgestellt.

Additional Material: 8 Ill.