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  • 1
    Electronic Resource
    Electronic Resource
    A possible role of the kidney in activating a renin preinhibitor (1975)
    Springer
    Research in experimental medicine 166 (1975), S. 201-207 
    Details
    ISSN: 1433-8580
    Keywords: Phospholipid renin preinhibitor ; Conversion to lysophospholipid renin inhibitor ; Human plasma ; Human kidney homogenate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to verify the possibility than human plasma and kidney can activate a renin preinhibitor (Phospholipid) into inhibitor (lysophospholipid), constant quantities of preinhibitor were added to plasma and kidney homogenate. Addition of preinhibitor to plasma did not modify the quantity of Angiotensin I that developed. On the other hand, addition of preinhibitor to crude kidney homogenate, followed by incubation with human angiotensinogen, caused a significant fall in the quantity of Angiotensin I generated. While plasma is deficient in the specific enzyme delegated to the transformation of preinhibitor into inhibitor, it appears that this enzyme is present in the kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852632
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Oxalate transport in cultured porcine renal epithelial cells (1992)
    Springer
    Urological research 20 (1992), S. 341-345 
    Details
    ISSN: 1434-0879
    Keywords: LLCPK 1 ; Cell culture ; Anion transport ; Kidney stones ; DIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Oxalate-containing kidney stones are the most common type (75%) of renal stones. In order to control oxalate excretion in the urine, a basic understanding of the cellular transport of oxalate is imperative. We have utilized the technique of continuous cell culture to establish and characterize a model system to study renal epithelial cell (LLCPK1) oxalate transport. Our data demonstrate that oxalate uptake in these cells is dependent on time, concentration and energy. TheK m for oxalate uptake was 200 μm. Oxalate uptake was decreased at lower temperatures and elevated in an acidic extracellular environment. Both anion exchange inhibitors DIDS and SITS inhibited oxalate oxalate uptake. Sulfate, chloride, and bicarbonate decreased oxalate uptake, as did the diuretics bumetanide and furosemide. There was no evidence for the co-transport of oxalate with sodium. Our data show that monolayers of cultured kidney epithelial cells are a valuable model system for study of the basic cellular mechanisms of oxalate transport.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00922746
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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