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Digitale Medien

Dopaminergic D-1 receptors: essential role in morphine-induced hypermotility (1987)

Longoni, R. ; Spina, L. ; Chiara, G.

Springer

Psychopharmacology 93 (1987), S. 401-402

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Details

ISSN: 1432-2072

Schlagwort(e): Morphine ; Dopamine ; Hyperactivity ; D-1 receptor ; SCH 23390 ; Mouse

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Administration of morphine HCl (20 mg/kg SC) to male C57B1/6 mice evoked hypermotility. Pretreatment with low doses of the specific D-1 antagonist SCH 23390 (0.006, 0.012, 0.025 mg/kg SC) dose-dependently inhibited morphine-evoked hypermotility. The results suggest that dopamine is the essential mediator of opiate hypermotility and indicate that D-1 receptors play an important role in this effect.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00187265

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