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  • 1
    Electronic Resource
    Electronic Resource
    In vivo release of neurotransmitters in the medial basal hypothalamus of the monkey (1984)
    Springer
    Experimental brain research 54 (1984), S. 575-578 
    Details
    ISSN: 1432-1106
    Keywords: Push-pull cannula ; Hypothalamus ; Neurotransmitters ; LH ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In vivo release rates of norepinephrine (NE), epinephrine (E), dopamine (DA), gammaaminobutyric acid (GABA), glutamate (GLU) and beta-endorphin (βE) in the medial basal hypothalamus (MBH) of unanaesthetized female macaca fascicularis monkey, and the effects thereon of estrogen (E2) treatment, have been estimated using pushpull perfusion methodology. DA, NE, E, GABA, GLU and βE were all detectable in 30 min perfusate fractions. No direct correlation between their release rates and those of LH and PRL could be observed. E2 induced an initial decrease, then an increase, in LH and PRL secretion, and concomitant changes in the release patterns of DA, NE, E. GABA and GLU were apparent. This study demonstrates that in vivo push-pull perfusion methodology may be applied to the unanaesthetized monkey, and when combined with venous catheterization for serial blood sampling may prove to be a powerful tool in the investigation of the central molecular events governing neuroendocrine functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235484
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in mediobasal hypothalamic dopamine and GABA release: A possible mechanism underlying taurine-induced prolactin secretion (1998)
    Springer
    Amino acids 15 (1998), S. 5-11 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Taurine ; Prolactin ; Dopamine ; GABA ; HPLC ; Hypothalamus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Taurine (Tau), a putative inhibitory amino acid neurotransmitter, has been shown to stimulate prolactin (PRL) release. Using ovariectomized, estrogen-replaced adult rats we investigated initially the effect of this amino acid, injected by different routes, on PRL secretion in vivo. Tau (100–500 mg/kg) had no effect on PRL release when given i.p.; 15 min after i.c.v. injection of Tau (3μmoles), a significant increase in serum PRL levels was observed (78 ± 9 ng/ml over basal levels, p 〈 0.01 vs. controls). In vitro (cultured anterior pituitary cells) PRL release was not affected by a 5 h incubation with Tau (10−3–10−8 M). Basal dopamine (DA) or gamma-aminobutyric acid (GABA) output from superfused mediobasal hypothalamic fragments (MBH) was not affected by Tau (10−3 M or 10−5 M). However, during stimulation with KCl (50mM), Tau (10−3 M) significantly lowered DA release, and increased GABA output. It is concluded that Tau acts at a central level to increase PRL secretion, most probably by modulating the hypothalamic release of neurotransmitters controlling lactotroph function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01345276
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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