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  • 1
    Electronic Resource
    Electronic Resource
    The freshwater snail Bulinus tropicus (Planorbidae) in Namibia, characterised according to chromosome number, enzymes and morphology (1996)
    Springer
    Hydrobiologia 317 (1996), S. 127-139 
    Details
    ISSN: 1573-5117
    Keywords: Mollusca ; Bulinus ; freshwater snails ; taxonomy ; distribution ; Africa ; Namibia ; Schistosoma haematobium ; schistosomiasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Freshwater snails collected in central Namibia, south-western Africa, from 15 populations belonging to the Bulinus truncatus/tropicus complex (Planorbidae) are characterised in respect of their chromosome number, morphology, egg proteins and enzymes. The population samples were all consistently diploid and euphallic. The findings are compared with observations on this group of snails in other areas of Africa. It is concluded that the Namibian populations belong to a single species, B. tropicus (Krauss, 1848), of which B. parietalis (Mousson, 1887) is probably a synonym. No evidence was found of any occurrence of the tetraploid species B. truncatus or of snails belonging to the B. africanus group; lack of a potential intermediate host therefore precludes transmission of Schistosoma haematobium in this area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00018736
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines (1996)
    Springer
    Breast cancer research and treatment 38 (1996), S. 67-73 
    Details
    ISSN: 1573-7217
    Keywords: epidermal growth factor ; EGF receptor ; quinazolines ; IGF-I ; TGFα ; tyrosine kinase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Since the mitogenic action of EGF is mediated by ligand-induced autophosphorylation of the EGF receptor (EGFR), and EGFR is commonly overexpressed in solid human tumours, inhibitors of receptor tyrosine kinase activity (RTK) could prove to be effective antitumour agents. Screening of a compound library using an EGF-RTK enzyme prepared from human tumour derived A431 cells identified a series of potent (IC50〈1µM) enzyme inhibitors. These inhibitors are quinazolines bearing a variety of substituted anilines at the 4-position. The most potent 4-anilinoquinazolines (IC50 ≅ 20nM) have small non-polar meta substituents on the aniline ring, and are competitive with ATP and non-competitive with substrate. The growth inhibitory activity of these agents was assessed in vitro using KB cells (human oral squamous tumour) grown in the absence or presence of EGF. A selected compound, 4-(3-chloroanilino)quinazoline (CAQ), inhibited EGF-stimulated growth in a concentration dependent manner and complete blockade was observed at concentrations (1–10 µM) which had no effect on basal growth. Selectivity of growth inhibition by CAQ was further exemplified in IGF1-stimulated KB cells where no effect was detected at concentrations which completely blocked EGF-stimulated growth. Similarly, CAQ blocked TGFα-stimulated growth in MCF-7 human breast cancer cells without affecting insulin-stimulated growth. These studies define a novel class of EGF-RTK inhibitors which are also potent and selective inhibitors of EGF-stimulated human tumour cell growthin vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01803785
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Freshwater snails of East Caprivi and the lower Okavango River Basin in Namibia and Botswana (1992)
    Springer
    Hydrobiologia 246 (1992), S. 9-40 
    Details
    ISSN: 1573-5117
    Keywords: Mollusca ; Gastropoda ; freshwater snails ; taxonomy ; distribution ; Africa ; Namibia ; Botswana ; Okavango River
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A systematic account is given of the aquatic gastropod fauna of the lower Okavango River in Namibia and Botswana, and of the East Caprivi area in Namibia, based on collections made mostly in 1983–86 from about 100 different sites. A total of 20 living species are reported, 9 of them for the first time from this area: Bellamya monardi, Lobogenes michaelis, Cleopatra elata, Afrogyrus coretus, Segmentorbis angustus, S. kanisaensis, Bulinus scalaris, B. depressus and B. tropicus. All are found outside this area and most are widely distributed Afrotropical species. Some do not occur farther south than the Okavango Delta, while others reach a south-western limit here but occur at greater latitude in the eastern tropical corridor on the coast of Natal. Bulinus globosus and Biomphalaria pfeifferi occur throughout the study area and are intermediate hosts for schistosome parasites of man and livestock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00005620
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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