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Digitale Medien

Unique 3′-untranslated sequence of insulin-like growth factor-I isolated from human placenta (1991)

Daimon, M. ; Wang, C.-Y. ; Johnson, T. R. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Molecular Reproduction and Development 29 (1991), S. 238-244

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Details

ISSN: 1040-452X

Schlagwort(e): IGF-IA ; Long 3′-end ; Expression ; Transcripts sizes ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie

Notizen: A cDNA clone of 525 bp corresponding to the 3′-untranslated region of insulin-like growth factor-I was isolated from a human placenta library. The sequence of this clone extended 200 nucleotides downstream from the previously reported 3′-end of IGF-IA cDNA, indicating the existence of IGF-IA transcripts having an even larger 3′-untranslated region. By using this clone for RNA transfer blot hybridization, it was shown that this longer 3′-untranslated region is included in the 7.5- and 5.0-kb transcripts, but not in the 1.1- and 0.9-kb transcripts. It is also apparent that transcripts bearing the extended 3′-untranslated sequence are highly expressed in human placenta.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/mrd.1080290305

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