ISSN:
1432-1912
Keywords:
Prejunctional α-adrenoceptors
;
Postjunctional α-adrenoceptors
;
Imidazolidines
;
Clonidine
;
Rabbit ear artery
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The pre- and postjunctional α-adrenergic agonist potency of a series of aryliminoimidazolidines was determined in the isolated rabbit ear artery. This series included clonidine, an antihypertensive agent thought to act by stimulating brainstem α-receptors and known to be a preferentially prejunctional α-adrenergic agonist. Although all of the compounds acted preferentially on the prejunctional α-adrenoceptor, ring substitution had a dramatic effect on both potency and the degree of selectivity. 2-(3,4-Dihydroxyphenylimino) imidazolidine was both the most potent and most selective prejunctional α-agonist in this series.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00504753
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