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  • 1
    Electronic Resource
    Electronic Resource
    Hyporesponsiveness of peripheral blood lymphocytes to streptococcal superantigens in patients with guttate psoriasis: evidence for systemic stimulation of T cells with superantigens released from focally infecting Streptococcus pyogenes (1999)
    Springer
    Archives of dermatological research 291 (1999), S. 382-389 
    Details
    ISSN: 1432-069X
    Keywords: Key words Psoriasis ; Streptococcus ; Superantigens ; T cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Throat infection with Streptococcus pyogenes is the most important trigger for acute guttate psoriasis. We examined the in vitro responses of peripheral blood mononuclear cells (PBMC) to streptococcal superantigens, SPEA and SPEC, and staphylococcal superantigens, SEB and TSST-1, in patients with guttate psoriasis, in patients with chronic plaque psoriasis, and in healthy subjects. PBMC from patients with guttate psoriasis responded poorly to SPEA and SPEC at concentrations of 0.1 and 1 ng/ml as compared with those from patients with plaque psoriasis, but showed high responses to SEB and TSST-1. The hyporesponsiveness recovered after improvement of the skin eruption. There was no significant difference between guttate and chronic types of psoriasis in the percentage of circulating T-cell receptor BV2 or BV8-bearing T cells, responsive to streptococcal superantigens, indicating that T-cell clonal anergy was a mechanism underlying the hyporesponsiveness. Our results suggest that superantigens released from focally infecting S. pyogenes induce a transient activation of relevant T cells, leading to the development of skin eruption and, subsequently, temporary T-cell anergy to these toxins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050426
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro activation of immune lymph node cell proliferation by photohapten-modified cells in murine contact photosensitivity (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 203-209 
    Details
    ISSN: 1432-069X
    Keywords: 3,3′,4′,5-Tetrachlorosalicylanilide ; Murine contact photosensitivity ; Immune lymph node cell proliferation ; Ultraviolet A radiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Painting of 3,3′,4′,5-tetrachlorosalicylanilide (TCSA) plus ultraviolet A (UVA) irradiation to the same site induces contact photosensitivity (CPS), but at the same time results in death of the photohapten-modified cells. Using an in vitro immune lymph node cell (LNC) proliferation system, we investigated the mechanism of induction and elicitation of CPS by TCSA painting plus UVA irradiation. The proliferation of LNC from TCSA-photosensitized mice was not augmented by the addition of TCSA-photocoupled syngeneic spleen cells (SC) or epidermal cells (EC), whereas the picryl chloride immune LNC proliferation was activated by trinitrophenyl-coupled (TNP-coupled) SC or EC. While the viability of SC and EC was unchanged even after TNP haptenization, cells showed very low levels of viability after TCSA photohaptenization. This suggests that the inability of photoTCSA-modified cells to activate LNC proliferation is because of their low viability. Nylon wool column purified lymph node T cells from TCSA-photosensitized mice were activated by photohapten-conjugated SC or photohaptenized EC fragments only in the presence of peritoneal macrophages (MΦ). The function of live MΦ was not replaced by interleukin-1 (IL-1), suggesting that MΦ were required for processing and/or presentation of photohapten rather than simply providing IL-1. Our in vitro study implies that photoTCSA-modified cells generated in vivo require intact antigen-presenting cells to effectively induce and elicit the CPS reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372063
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sparfloxacin phototoxicity: potential photoaugmentation by ultraviolet A and B sources (1995)
    Springer
    Archives of dermatological research 288 (1995), S. 45-50 
    Details
    ISSN: 1432-069X
    Keywords: Key words DNA strand-breaking activity ; Photoaugmentation ; Phototoxicity ; Sparfloxacin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sparfloxacin, a quinolone antibacterial agent, frequently elicits photosensitive skin reactions. Our clinical studies of patients treated with sparfloxacin have demonstrated that this photosensitivity is primarily phototoxic and that a marked erythematous response is induced by sequential irradiation with ultraviolet A (UVA) and B (UVB) but not UVA or UVB alone, suggesting potential synergism between UVA and UVB. We evaluated the phototoxicity of this agent using in vitro DNA breaking activity and in vivo murine cutaneous responses. Sparfloxacin induced DNA strand breaks in vitro and converted the supercoiled closed circular form of plasmid DNA to the open circular form by its photodynamic action. In mice, the topical application of sparfloxacin and subsequent irradiation with UVB, but not UVA, induced ear swelling responses. However, the UVB-induced ear swelling response was augmented by irradiation with UVA before or after UVB exposure. Such interaction between UVA and UVB in the production of ear swelling was further confirmed by systemic administration of sparfloxacin. Our study suggests that sparfloxacin is a unique phototoxic agent in that photosensitivity dermatitis is evoked by photoaugmentation between UVA and UVB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050021
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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