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  • Immunoblastic lymphoma  (1)
  • UVA-radiation  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Sézary syndrome with early immunoblastic transformation (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 17-26 
    Details
    ISSN: 1432-069X
    Keywords: Skin ; Sézary syndrome ; T-cell leukemia/lymphoma ; Immunoblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two patients with clinical manifestations of Sézary syndrome are reported. In both cases from an early stage of the disease in addition to characteristic Sézary cells large numbers of immunoblasts were present in skin lesions and peripheral lymph nodes and in one case also in the blood. Their relationship to the characteristic Sézary cells was shown by morphological, cytochemical and immunological methods. The infiltrates in the skin were epidermotropic in one case and nonepidermotropic in the other. Lymph node structure was effaced by diffuse infiltration of abnormal lymphoid cells. These were found to proliferate in the skin as well as in lymph nodes. Cytogenetical studies of blood lymphocytes indicated an abnormal hypodiploid clone in both cases. Immunologically the tumour cells had properties of peripheral T-lymphocytes but whereas all abnormal cells exhibited inducer/helper cell characteristics in one case, only a minority of the lymphocytes revealed these characteristics in the other case. In this case the tumour cell population changed into a more pleomorphic type. The classification of the cases is discused.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412557
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    UVA-induced tumours in pigmented hairless mice and the carcinogenic risks of tanning with UVA (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 289-294 
    Details
    ISSN: 1432-069X
    Keywords: UVA-radiation ; Tanning ; Carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An animal experiment is presented in which two groups of pigmented hairless mice were exposed daily to suberythemal doses of UVA to study tumourigenesis. The aim of the study was to estimate the carcinogenic risks of tanning by UVA. The pigmented hairless mice, Skh-hr2, were separated by selective breeding into two groups, the “browns” and the “blacks”. Both groups were exposed daily to UVA from fluorescent UVA lamps (Philips TL40W/09) purified by rigorously filtering out the shorter wavelengths. No acute actinic damage was observed after any exposure. However, in most UVA exposed animals, especially in the blacks, a marked scratching preceded the development of tumours. Hyperkeratosis was also observed. All animals developed tumours. Histopathologically at least 60% of the tumours were squamous cell carcinomas. Depositions of melanophages were observed, but no melanomas. It is beyond any doubt that UVA is carcinogenic in laboratory animals. The present state of knowledge justifies no preference for tanning with UVA over tanning with UVB.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375721
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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