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  • Immunocompetence  (1)
  • Mitochondrial encephalomyopathy  (1)
  • Pseudohypoparathyreoidismus  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pseudohypoparathyroidism and hypocalcemic “myopathy” (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 1195-1199 
    Details
    ISSN: 1432-1440
    Keywords: Fallbericht ; Pseudohypoparathyreoidismus ; hypocalcämische Myopathie ; Case report ; Pseudohypoparathyroidism ; Hypocalcemic myopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A patient with the clinical features of pseudohypoparathyreoidism and elevated concentrations of serum CK and LDH, which normalized after successful therapy, is described. Clinical signs of myopathy did not exist. The bioptical material from the m. tibialis anterior was microscopically normal. The biochemical analysis revealed a reduced phosphorylase-a-activity with the total phosphorylase-activity (a and b) being within the normal range. The significance of these findings as well as possible pathogenetic mechanisms are discussed.
    Notes: Zusammenfassung Es wird über einen Fall von Pseudohypoparathyreoidismus berichtet, bei dem gleichzeitig erhöhte CPK- und LDH-Konzentrationen im Serum festgestellt wurden, die sich nach Therapie normalisierten. Klinische Zeichen einer Myopathie bestanden nicht. Das Biopsiematerial vom m. tibialis anterior war mikroskopisch unauffällig. Biochemisch fand sich eine verminderte Phosphorylase-a-Aktivität bei normaler Gesamtphosphorylase-Aktivität (a und b). Die Bedeutung des Befundes und die möglichen pathogenetischen Mechanismen werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721214
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    HTLV-III antibody prevalence among young delinquent drug abusers in long-term residential treatment at a north-German drug clinic (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 22-26 
    Details
    ISSN: 1432-1440
    Keywords: Intravenous drug abusers ; Acquired immunodeficiency syndrome ; Immunocompetence ; Longitudinal study ; LAV/HTLV-III
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To date, long-term intravenous drug users studied at regional European centers of illicit drug use have had a high number of LAV/HTLV-III infections. Among 200 patients remanded by court or referred from prison to a special clinic in northern Germany for young delinquent drug abusers, 26 (17%) of 157 IV drug abusers were HTLV-III seropositive. With 40% seropositive, female patients showed a significantly higher prevalence of HTLV-III infection than males. The results of longitudinal serological, immunological, and clinical observations over periods of 12 months and 2–3 years indicate that under conditions of continuous medical surveillance, sound preventive counseling, and steady therapeutic care during long-term coeducative residential treatment of drug abusers, neither detectable HTLV-III transmission nor definite progression of HTLV-III induced impairment of immune regulatory functions must ensue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01785522
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Mitochondrial encephalomyopathy, lactic acidosis and stroke in adults: two cases (1993)
    Springer
    Journal of neurology 240 (1993), S. 219-222 
    Details
    ISSN: 1432-1459
    Keywords: actic acidosis ; MELAS ; Mitochondrial encephalomyopathy ; Stroke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two previously healthy women are described who in their late thirties suffered transient strokelike episodes, consisting of initial headache and vomiting, with various subsequent neurological signs that were only partially reversible. Investigations revealed elevated serum creatine kinase, lactic acidosis, hypertriglyceridaemia, and ragged red fibres in the muscle biopsy specimens. In both patients in vitro studies were performed on intact muscle mitochondria and muscle homogenate. Only in one was a mitochondrial defect found, located at the level of coenzyme Q. We conclude that these patients suffered from adult-onset mitochondrial encephalopathy, lactic acidosis and strokelike episodes (MELAS syndrome). Although the syndrome is often associated with long-standing neurological multisystem disease from childhood onwards, it should also be suspected in adults with strokelike signs of otherwise unexplained origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00818708
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    Paper (German National Licenses)
    Fulltext
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