ISSN:
1619-7089
Keywords:
Colorectal cancer
;
Human monoclonal antibody99mTc-88BV59
;
Radioimmunoscintigraphy
;
Immunogenicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This study presents immunoscintigraphic results in 24 patients suffering from primary colorectal cancer, recurrent or metastatic disease after the injection of 1197–1351 MBq technetium-99m labelled totally human monoclonal antibody 88BV59. Labelling efficacy of99mTc-88BV59 ranged from 97% to 99%. Immunoscintigraphy was performed 18–20 h after injection. Scintigraphic findings were compared with those of computed tomography (CT). Patients underwent surgery in order to evaluate immunoscintigraphic findings histologically. Sera of the patients (before injection and 1 and 3 months post infusion) were analysed for the presence of human anti-human antibodies (HAHA). None of the patients showed a HAHA response as assessed by a solid-phase ELISA assay. The antibody scan detected about 25% more lesions than CT. In the detection of extrahepatic disease, the sensitivity of the antibody scan proved to be 68%, whereas the sensitivity of CT was 41%.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01728312
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