Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    In situ demonstration of parathyroid hormone-related protein mRNA in sclerosing hepatic carcinoma (1999)
    Springer
    Virchows Archiv 435 (1999), S. 137-142 
    Details
    ISSN: 1432-2307
    Keywords: Key words Sclerosing hepatic carcinoma ; Hypercalcaemia ; Parathyroid hormone-related protein (PTHrP) ; Immunohistochemistry ; In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 69-year-old man had a hepatic tumour occupying the left and half of the right lobe, with portal vein thrombus. There were hypercalcaemia and hypophosphataemia with increased nephrogenous cyclic adenosine monophosphate; bone metastases were excluded. Serum parathyroid hormone-related protein (PTHrP) was elevated, but no increase in intact parathyroid hormone (PTH) or vitamin D3 metabolites was found. At autopsy the histological features were typical of sclerosing hepatic carcinoma. By immunohistochemistry PTHrP was detected in cancer cell nests but not in the fibrous stroma. PTHrP transcripts were demonstrated by in situ hybridization using a polymerase chain reaction (PCR)-derived single-stranded DNA probe. Tumour cells expressed AE1 and CA19-9 (markers for cholangioepithelium) and CEA (for bile canaliculi). Electron microscopy revealed microvilli on the apical surface, and secretory granules 100 nm in diameter were observed. These findings indicate that this case is one of cholangiocellular sclerosing hepatic carcinoma. The interaction between cancer and stromal cells may be the cause of PTHrP overexpression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050411
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Parathyroid hormone-related protein (PTH-rP)-producing lung cancer with psoas abscess-like metastasis and humoral hypercalcemia of malignancy (2000)
    Springer
    International journal of clinical oncology 5 (2000), S. 410-413 
    Details
    ISSN: 1437-7772
    Keywords: Key words Humoral hypercalcemia of malignancy (HHM) ; Lung cancer ; Psoas abscess-like metastasis ; Parathyroid hormone-related protein (PTH-rP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a patient with lung cancer associated with psoas abscess-like metastasis and humoral hypercalcemia of malignancy (HHM). A 71-year-old man was hospitalized with exacerbating pain on the left-side of his back and thigh. A computed tomography (CT) scan of the abdomen demonstrated a tumor in the left iliopsoas muscle, first diagnosed as psoas abscess. A chest roentgenogram showed right-sided pleural effusion, and CT scan of the chest demonstrated a tumor in the right lower lobe of the lung. His serum calcium level was 12.8 mg/dl, and parathyroid hormone-related protein (PTH-rP) level was elevated, to 11.1 pmol/l. The patient died of progressive disease, and necropsy specimens were diagnosed as poorly differentiated squamous cell carcinoma. Immunohistochemical staining for PTH-rP was positive in the tumor cells, including the primary and the metastatic lesions. A review of this unusual tumor type is also presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...