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  • Immunohistochemistry  (1)
  • Sodium iodide 131  (1)
  • doxorubicin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Occurrence of epidermal growth factor receptors in benign and malignant ovarian tumors and normal ovarian tissues: an immunohistochemical study (1992)
    Springer
    Journal of cancer research and clinical oncology 118 (1992), S. 303-307 
    Details
    ISSN: 1432-1335
    Keywords: EGF receptors ; Immunohistochemistry ; Ovarian carcinomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epidermal growth factor receptor (EGF-R) was studied with monoclonal antibody 2E9 on 50 ovarian tumors of various histological types and 10 non-tumorous ovarian tissues by immunohistochemistry. Enhanced expression was observed in 26/50 (52%) of the tumors. Only 25 out of 46 epithelial tumors (54%) showed positivity in epithelial tumor cells. Staining was cytoplasmic in all cases. No correlation was established between EGF-R expression and the histological type of the epithelial tumor. Apart from EGF-R expression in tumor cells, low immunoreactivity was also observed in stromal and endothelial cells in both normal and tumorous ovarian tissues. Furthermore in 8/9 specimens containing necrotic areas, EGF-R was noticed in these areas as well. Both of the latter observations may have impact on the evaluation of the prognostic value of EGF-R activity in tumors, when based on EGF-R measurements using biochemical binding studies. We therefore recommend that EGF-R is measured with both methods in studies regarding its clinical value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01208620
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Uterine radiation dose from open sources: the potential for underestimation (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 94-95 
    Details
    ISSN: 1619-7089
    Keywords: Uterine radiation dose ; Sodium iodide 131 ; Underestimation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The evaluation of the risk of radiation damage to the unborn child as the result of the administration of radionuclides remains a subject for discussion (Mountford 1989). Lack of information concerning the biodistribution of radiopharmaceuticals in the early stages of pregnancy, before organogenesis has occurred, has greatly restricted the objective assessment of fetal doses. Recent observations on the biodistribution of a therapeutic dose of sodium iodide 131 in a patient with an unsuspected early pregnancy lead us to suspect that current dose estimates with respect to uterine exposure (ARSAC 1988) may seriously underestimate the actual exposure of the developing fetus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00819411
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Weekly low-dose mitoxantrone plus doxorubicin as second-line chemotherapy for advanced breast cancer (1992)
    Springer
    Breast cancer research and treatment 21 (1992), S. 133-138 
    Details
    ISSN: 1573-7217
    Keywords: breast cancer ; chemotherapy ; doxorubicin ; mitoxantrone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Weekly low dose mitoxantrone (3 mg/m2) plus doxorubicin (8 mg/m2) was administered as second-line chemotherapy to 33 patients with advanced breast cancer. Four out of 28 evaluable patients (14%) obtained a partial response with a median duration of 34 weeks (range 18–67+ weeks), while 8 patients (29%) showed stable disease with a median duration of 28 weeks (range 11+–60 weeks). Gastrointestinal toxicity and alopecia were mild. Grade II and III leukopenia occurred in 63% of the courses without serious infectious disease. Four patients experienced an asymptomatic drop of 16–20% in the left ventricular ejection fraction (LVEF) after relatively low cumulative doses of each drug, and one patient with a history of pericarditis carcinomatosa and mediastinal irradiation developed a heart failure. In conclusion, this second-line combination treatment had moderate activity in breast cancer and caused only few subjective side effects, especially with respect to gastrointestinal symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01836959
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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