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  • 1
    ISSN: 1437-7772
    Keywords: Key words Hepatocellular carcinoma ; Carcinosarcoma ; Mesenchymal differentiation ; Immunohistochemistry ; Hepatectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of hepatocellular carcinoma associated with mesenchymal differentiation, which was identified as a true carcinosarcoma based on thorough pathologic examination. A 48-year-old man presented with a giant mass in the lateral segment of the liver. It was resected by lateral segmentectomy combined with total gastrectomy. Microscopically, the tumor consisted of hepatocellular carcinoma, osteosarcoma, and undifferentiated sarcomatous components. The undifferentiated sarcomatous components were positive for cytokeratin, whereas the osteosarcomatous components were negative for cytokeratin and positive for S100. To our knowledge, this is only the second known case in which mesenchymal differentiation was immunohistochemically demonstrated in liver carcinosarcoma.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1860-1499
    Keywords: Small intestine ; Carcinoma ; Linitis plastica ; Immunohistochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We examined a case of an 87-year-old man who had had a 1-month history of ileus of unknown cause. Postmortem examination revealed numerous foci of constriction and thickening throughout the small intestine, associated with perforation and panperitonitis. Histologically. diffuse infiltration of anaplastic atypical cells was found in the wall of almost the entire small intestine. The atypical cells were immunohistochemically positive for carcinoembryonic antigen and epithelial membrane antigen. In the electron microscopic examination, most of those cells had microvilli with filamentous core rootlets and terminal webs. There was no atypical cell infiltration in the stomach or large intestine. We concluded that this case was primary linitis plastica type carcinoma of the small intestine involving almost the entire small intestine.
    Type of Medium: Electronic Resource
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