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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical and morphological investigations of 30 human insulinomas (1973)
    Springer
    Diabetologia 9 (1973), S. 217-231 
    Details
    ISSN: 1432-0428
    Keywords: Insulinoma ; IRI content of insulinoma ; ultrastructural categorization of insulinomas ; proinsulin content of insulinomas ; functional defect in insulinomas reduced storage capacity of insulinoma cells ; non-granular insulin release ; proinsulin content of human pancreas ; diazoxide response of insulinomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty human insulinomas have been investigated histologically and their immunoreactive insulin (IRI) content estimated. In most cases immunohistological and ultrastructural studies were also performed and the percentage of proinsulin-like components (PLC) in the tumour determined. Except for 1 case the IRI concentration in the tumours was lower (0.01–89.0 U/g) than in the islet tissue. Histologically, immunohistologically and ultrastructurally a variable number of tumour cells contained few and often no beta-granules, indicating a decreased storage capacity for insulin. This defective storage capacity seems to be the major functional abnormality of insulinoma cells. Ultrastructurally four types of insulinoma can be distinguished. The ultra-structural diagnosis of an insulinoma can only be made in type I (typical beta-granules, 13 cases) and type II (typical and atypical granules, 7 cases) but not in type III (atypical granules only, 4 cases) and type IV (virtually agranular, 4 cases). The type IV tumours had the lowest IRI concentration and did not respond to diazoxide treatment. The IRI concentration of the uninvolved pancreas of 19 patients was 2.0±0.2 U/g and in the range of non-diabetic adults. — The percentage PLC in 19 insulinomas was higher (5.3–22%) than in the pancreas of human adults with and without insulinoma (1.7–4.8%). The percentage of PLC in the serum of patients with insulinoma was always higher than in their tumours (33–61%). It is suggested that the higher PLC levels found in the tumour and serum of insulinoma patients are the consequence of the reduced storage capacity of the tumour cells resulting in a rapid passage through the granular route or even a non-granular release of newly synthesized insulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219786
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Diets rich in natural fibre improve carbohydrate tolerance in maturity-onset, non-insulin dependent diabetics (1981)
    Springer
    Diabetologia 20 (1981), S. 18-21 
    Details
    ISSN: 1432-0428
    Keywords: Carbohydrate tolerance ; dietary fibre ; diabetes mellitus ; plasma glucose ; insulin ; gastric inhibitory polypeptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of low and high fibre diets upon carbohydrate tolerance was examined in five maturity-onset, non-insulin dependent diabetics. After 14 days on a diet rich in natural fibre (30g/ day), the subjects consumed a high fibre (13 g) test meal. They then ate a low fibre diet (10 g/day) followed by a low fibre (1 g) test meal. Mean basal plasma glucose concentrations were similar after both fibre diets; however, both mean basal plasma. insulin and gastric inhibitory polypeptide (GIP) were significantly lower after the high fibre diet. Affer the high fibre test meal, significantly lower mean plasma glucose, insulin and GIP concentrations were measured. This study is the first study to demonstrate the ability of an institutionally supervised diet of natural foodstuffs rich in fibre to improve carbohydrate tolerance in maturity-onset, non-insulin dependent diabetics. This finding is relevant to the dietary management of diabetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253811
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Diets rich in natural fibre improve carbohydrate tolerance in maturity-onset, non-insulin dependent diabetics (1981)
    Springer
    Diabetologia 21 (1981), S. 18-21 
    Details
    ISSN: 1432-0428
    Keywords: Carbohydrate tolerance ; dietary fibre ; diabetes mellitus ; plasma glucose ; insulin ; gastric inhibitory polypeptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of low and high fibre diets upon carbohydrate tolerance was examined in five maturity-onset, non-insulin dependent diabetics. After 14 days on a diet rich in natural fibre (30 g/ day), the subjects consumed a high fibre (13 g) test meal. They then ate a low fibre diet (10 g/day) followed by a low fibre (1 g) test meal. Mean basal plasma glucose concentrations were similar after both fibre diets; however, both mean basal plasma insulin and gastric inhibitory polypeptide (GIP) were significantly lower after the high fibre diet. Affer the high fibre test meal, significantly lower mean plasma glucose, insulin and GIP concentrations were measured. This study is the first study to demonstrate the ability of an institutionally supervised diet of natural foodstuffs rich in fibre to improve carbohydrate tolerance in maturity-onset, non-insulin dependent diabetics. This finding is relevant to the dietary management of diabetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01789108
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Einfluß der selektiv proximalen Vagotomie mit und ohne Pyloroplastik auf die basale und postprandiale Gastrin-Freisetzung bei Ulcus-duodeni-Patienten (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 209-214 
    Details
    ISSN: 1432-1440
    Keywords: Immunoreactive gastrin ; selective proximal vagotomy ; fasting serum gastrin ; postprandial integrated gastrin output ; insulin test ; Immunoreaktives Gastrin ; selektive proximale Vagotomie ; Nüchternserumgastrin ; postprandiale integrierte Gastrinausschüttung ; Insulintest
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 17 Patienten mit Ulcus duodeni wurde der Einfluß der selektiven proximalen Vagotomie (SpV), in 12 Fällen kombiniert mit Pyloroplastik, auf die basale und postprandiale Gastrinfreisetzung untersucht. Dabei ergab sich ein Anstieg der Nüchterngastrinspiegel bei allen Patienten nach SpV. Dieser Anstieg des basalen Gastrinwertes war bei Patienten mit negativem postoperativem Insulintest höher als bei insulin-positiven Fällen. Die nach Hollander-Kriterien negativen, aber nach verschärften Kriterien (keine Säure basalund nach Insulinstimulation) positiven Fälle verhalten sich wie Hollander-positive Patienten hinsichtlich basalem pH und basalem Gastrinwert. Der integrierte Gastrinoutput (IGO) während 2 Std nach Testmahlzeit liegt nach SpV im Mittelwert höher, ist jedoch infolge einer zu kleinen Fallzahl weder in der Gruppe mit noch in der Gruppe ohne Pyloroplastik signifikant vom präoperativen IGO unterschieden. Der postprandiale Serumgastrinanstieg unterscheidet sich bei den Patienten mit und ohne Pyloroplastik nicht signifikant. Nach Zusammenfassung beider Gruppen ergibt sich für die 17 Patienten, daß die SpV zu einem signifikant höheren postprandialen IGO führt.
    Notes: Summary The effect of selective proximal vagotomy (SpV) with (12 cases) and without (5 cases) pyloroplasty upon basal and food stimulated serum immunoreactive gastrin (IRG) was studied in duodenal ulcer patients. Following SpV, fasting serum IRG increased in all subjects; the increase was more pronounced in subjects whose postoperative insulin tests were negative. Postoperatively, the mean integrated IRG output over 2 hrs in response to a meal was significantly higher than the preoperative mean value in the 17 patients. Pyloroplasty had no effect upon the IRG response following a test meal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468809
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    Paper (German National Licenses)
    Fulltext
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