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  • In situ hybridization  (1)
  • Tachykinin receptor  (1)
  • exudative age-related macular degeneration  (1)
  • 1
    Electronic Resource
    Electronic Resource
    In situ hybridization analysis of substance P receptor in the rat retina (1996)
    Springer
    Experimental brain research 112 (1996), S. 181-186 
    Details
    ISSN: 1432-1106
    Keywords: Tachykinin receptor ; Retrograde cell labeling ; Optic nerve crush ; Ganglion cell layer ; Inner nuclear layer ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Substance P receptor is known to provide a principal interface between tachykinin peptides and tachykinin-sensitive cells in retinal circuitry and to produce several physiological functions such as excitation of ganglion cells. We reported results of in situ hybridization analysis of substance P receptor in rat retina using digoxigenin-labeled RNA probes to yield discrete cell labeling. Distinct hybridization signal was present in a great majority of ganglion cells that provide retinal fibers to a central target. It was also present in a subpopulation of amacrine cells. Following optic nerve crush, ganglion cells lost their hybridization signal in a time-dependent manner, while hybridization-positive amacrine cells were persistently seen. From the results, we identified the hybridization message as distinctly localized to two systems, output cells and intrinsic cells in retinal circuitry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227636
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Time-course expression of vascular endothelial growth factor as related to the development of the retinochoroidal vasculature in rats (1998)
    Springer
    Experimental brain research 118 (1998), S. 155-160 
    Details
    ISSN: 1432-1106
    Keywords: Key words Retinochoroidal vasculature ; Retinal pigment epithelium ; Vascular endothelial growth factor ; In situ hybridization ; Immunohistochemistry ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Growth factors involved in angiogenesis are critical to both the normal and pathological vascular development in the retina and choroid. In the present experiment, the relationship between the vascular endothelial growth factor (VEGF) expression and the retinochoroidal vasculogenesis in Sprague-Dawley rats was investigated using in situ hybridization and immunohistochemistry. It was found that VEGF was produced mainly by astrocytes and Müller cells in the neural retina, and this was correlated temporally and spatially with the retinal vasculogenesis. In addition, it was observed that, although the VEGF expression in the retinal pigment epithelium (RPE) decreased with increasing age, it persisted from the embryonic stage to adulthood. These findings indicate that the VEGF expression in RPE may play a role in the development of the choroidal vessels as well as in the maintenance of the normal structure and permeability of the choriocapillaris in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050267
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Report on the nationwide epidemiological survey of exudative age-related macular degeneration in Japan (1997)
    Springer
    International ophthalmology 21 (1997), S. 1-3 
    Details
    ISSN: 1573-2630
    Keywords: exudative age-related macular degeneration ; epidemiological survey ; annual number
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The research Committee on Chorioretinal Degeneration, incooperation with the Research Committee on theEpidemiology of Intractable Diseases, performed the secondnationwide epidemiological survey of exudative age-relatedmacular degeneration (AMD) in 1993. The number ofexudative AMD patients in all ophthalmology departmentsthroughout Japan was estimated to be 14,400 in 1993. Thisnumber was estimated to have almost doubled over the sixyear period since the initial survey in 1987. The number ofpeople visiting ophthalmology departments due to exudativeAMD was 53 males and 20 females per 100,000 populationaged 50 years or over. The percentage of patients withbilateral disease increased with age and accounted fornearly 50% of those aged 80 years or over.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005845521424
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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