ISSN:
1435-4373
Keywords:
Key words BAY 12-8039
;
In vitro activity
;
Anaerobic bacteria
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The in vitro activity of BAY 12-8039 against 360 anaerobic clinical isolates was determined by the agar dilution method and compared to that of five other antimicrobial agents. BAY 12-8039 and imipenem were the most active agents tested. The following MIC90 values were determined for BAY 12–8039 : Peptostreptococcus spp. (50 isolates), 1 mg/l;Propionibacterium acnes (30 isolates), 0.25 mg/l;Clostridium perfringens (30 isolates), 0.5 mg/l;Clostridium difficile (50 isolates), 2 mg/l;Bacteroides fragilis (50 isolates), 1 mg/l; non-fragilis Bacteroides, Porphyromonas, and Prevotella spp. (100 isolates), 2 mg/l; and Fusobacterium spp. (50 isolates), 0.25 mg/l. The results of the present study show that BAY 12-8039 may be useful in the treatment and prophylaxis of anaerobic infections.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01691117
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