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  • 1
    Electronic Resource
    Electronic Resource
    Endogenous respiration reflects the energy load imposed by transport of nonmetabolizable substrates and by induced de novo protein synthesis in Rhodotorula glutinis (1993)
    Springer
    Archives of microbiology 159 (1993), S. 541-544 
    Details
    ISSN: 1432-072X
    Keywords: Substrate uptake ; Energy requirement ; Endogenous respiration ; Nonmetabolized substrate ; Induced catabolism ; Rhodotorula glutinis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Uptake of the nonmetabolizable sugars 6-deoxy-d-glucose, l-rhamnose and l-xylose, which are taken up by a common carrier, stimulated significantly cell respiration in Rhodotorula glutinis. The extra oxygen consumption for uptake (0.5–0.7 equivalents O2/mol transported sugar) was proportional to the uptake rate and was independent of the K tvalue of the transport system. Sugars that become metabolized after induction, d-arabinose and methyl-α-d-glucoside, caused a higher stimulation, 1.4 and 3.6 equivalents O2/mol respectively, which was reduced to 0.6 equivalents O2/mol when de novo protein synthesis was blocked by cycloheximide. The stimulation of respiration thus includes a fraction related purely to the energy demand for uptake and another one related to the induced de novo protein synthesis. The net uptake-induced respiration boost was similar with all sugars under study irrespective of their transport systems. The estimated energy demand was equivalent to about 2 ATP/sugar molecule. For comparison, the amino acid analogue α-aminoisobutyric acid (AIB) was also investigated; the overall energy demand for its uptake corresponded to the equivalent of about 4 ATP/molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00249033
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  • 2
    Electronic Resource
    Electronic Resource
    Probleme der Rekonstruktion des Gallenabflusses bei der orthotopen Lebertransplantation (1987)
    Springer
    Langenbeck's archives of surgery 371 (1987), S. 49-58 
    Details
    ISSN: 1435-2451
    Keywords: Liver transplantation ; Bile duct reconstruction ; Biliary complications ; Bile sludge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Komplikationen bei der Gallenwegsrekonstruktion treten nach der Lebertransplantation häufig auf. Eine anatomisch bedingte unzureichende Blutversorgung der extrahepatischen Gallenwege führt postoperativ zur Gallengangsnekrose. Biliodigestive Anastomosen haben ein erhöhtes Risiko für ascendierende Infektionen im Transplantat. Gallensludgebildung verursacht eine intra- und extrahepatische Gallenwegsobstruktion. Heute werden hauptsächlich die Sphincterfunktion erhaltende Methoden zur Gallendrainage angewandt, entweder Choledocho-Choledochostomie oder Gallenblasen-Conduit-Methode. Falls dies anatomisch nicht möglich ist, verwendet man eine biliodigestive Anastomose mit einer ausgeschalteten Jejunumschlinge nach Roux. Wird eine Gallenwegskomplikation festgestellt, ist die sofortige operative Revision der Gallendrainage lebensrettend.
    Notes: Summary In hepatic transplantation complications of the biliary drainage were frequently observed. Ischemia of the extrahepatic bile duct which occurs for anatomical reasons can cause necrosis of the bile duct. The reconstruction of biliary drainage by biliodigestive anastomosis results in ascending infections of the graft. Biliary sludge could obstruct the intra- or extrahepatic bile duct. Recently, operation methods are mainly applied in which the function of Oddi's sphincter is preserved, i. e. choledocho-choledochostomy or gallbladder conduit method. If it is not possible to perform these methods the Roux-y jejunum loop is used. Finally, an immediate operative revision of the biliary drainage is indicated if its complication is diagnosed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01259243
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  • 3
    Electronic Resource
    Electronic Resource
    271. Tuberkulose nach lebertransplantation (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 893-894 
    Details
    ISSN: 1435-2451
    Keywords: Liver transplantation ; Pulmonary tuberculosis ; Tuberculostatic therapy ; Lebertransplantation ; Lungentuberkulose ; Tuberculostatica
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem 55jährigen Mann wurde 7 Monate nach orthotoper Lebertransplantation eine Lungentuberkulose diagnostiziert. Die tuberculostatische Therapie erfolgte mit Isoniazid (3 x 0,2 g/Wo) und Ethambutol (1,6 g/d) über 11 Monate. Nach 3 Monaten waren keine Mycobakte rien mehr nachweisbar, und der Patient ist im 3. Jahr nach Transplantation ohne Zeichen einer aktiven Tuberkulose in gutem Gesundheitszustand bei guter Transplantatfunktion. Die Tuberculostatica-Dosierung sollte je nach Metabolisierungsleistung des Transplantats reduziert werden. Bei Beachtung dieses Kardinalpunktes könnte eine Tuberkulose nach Lebertransplantation erfolgreich behandelt werden.
    Notes: Summary Pulmonary tuberculosis was clinically diagnosed and verified with sputum cultures in a 55-year-old patient 7 months after liver transplantation. After 3 months of tuberculostatic therapy with isoniazid (3 x 0.2 g/week) and ethambutol (1.6 g/day), sputum cultures became negative and therapy was discontinued after 11 months. The patient is now in the 3rd year after transplantation in good general condition with excellent graft function and no signs of active tuberculosis. The dosage of the tuberculostatic drugs should be reduced according to the metabolic state of the graft to avoid drug hepatotoxicity. Then tuberculosis after liver transplantation can be treated successfully.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298055
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