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  • 1
    Electronic Resource
    Electronic Resource
    Altered distribution of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4) and the N-methyl-d-aspartate receptor subunit NMDAR1 in the hippocampus of patients with temporal lobe epilepsy (1996)
    Springer
    Acta neuropathologica 92 (1996), S. 576-587 
    Details
    ISSN: 1432-0533
    Keywords: Key words Excitatory amino acids ; Therapy-refractory epilepsy ; Ammon’s horn sclerosis ; Quantitative image analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In patients with therapy-refractory temporal lobe epilepsy (TLE), alterations of glutamate receptors have been proposed as a mechanism for enhanced excitability. Using commercially available monoclonal antibodies specific for the N-methyl-d-aspartate (NMDA) receptor subunit NMDAR1 and for the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit GluR2(4), we have examined the distribution of these polypeptides in human hippocampal tissue that was surgically removed from patients with intractable TLE. Surgical specimens were classified according to the presence of Ammon’s horn sclerosis (AHS) or a focal lesion in the temporal lobe. Cell counts and a densitometric analysis of the immunoreactivity patterns were carried out for all hippocampal subfields. NMDAR1 and GluR2(4) levels were markedly reduced in patients with AHS, primarily in those subfields with substantial neuronal cell loss (in particular CA1, CA4 and CA3), compared to those seen in patients with focal lesions and in control specimens obtained at autopsy. In contrast, the molecular layer of the dentate gyrus (DG-ML) showed significantly higher levels of GluR2(4) immunoreactivity in AHS compared to control tissue, while NMDAR1 showed no significant up-regulation in this sublayer. When the receptor staining intensity was normalized for alterations in neuronal density, no significant alterations could be detected except for an increase in GluR2(4) in the DG-ML of patients with AHS. These changes may reflect synaptic reorganization observed in the DG-ML of specimens from patients with chronic intractable TLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050564
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  • 2
    Electronic Resource
    Electronic Resource
    Lüftungseigenschaften von Laborabzügen (Digestorien) (1964)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 36 (1964), S. 455-460 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Es wurden fünf Abluftsysteme von Laborabzügen auf den erforderlichen Luftdurchsatz untersucht. Dabei zeigte sich, daß die Durchlüftung von Abzügen bei nahezu geschlossenem Frontschieber praktisch unabhängig von der Anordnung der Absaugeöffnung ist. Der Einfluß von äußeren Störungen bei geöffnetem Schieber zeigt, daß die abzusaugende Luftmenge nur dann in wirtschaftlich vertretbarer Größe bleibt, wenn man bei nahezu geschlossenem Abzug arbeitet.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330360507
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    Paper (German National Licenses)
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