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  • Inorganic Chemistry  (2)
  • Septum  (2)
  • Tyrosine hydroxylase induction  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Modulation of mRNA expression of the neurotrophins of the nerve-growth-factor family and their receptors in the septum and hippocampus of rats after transient postnatal thyroxine treatment. II. Effects on p75 and trk receptor expression (1999)
    Springer
    Experimental brain research 127 (1999), S. 307-313 
    Details
    ISSN: 1432-1106
    Keywords: Key words Thyroid hormone ; RT-PCR ; p75 receptor ; trkA ; trkB ; trkC ; Septum ; Hippocampus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Early postnatal application of thyroid hormones to rats results in morphological changes of the septo-hippocampal cholinergic and the hippocampal mossy fiber systems. Modulation in the expression of either neurotrophins and/or their receptors is postulated to be involved in these effects. In a recent study, we showed that, after thyroxine application, the mRNA expression of neurotrophins of the nerve-growth-factor (NGF) family is significantly upregulated both in septum and hippocampus. To test whether the neurotrophin receptors (the low-affinity neurotrophin receptor p75 and the specific high-affinity receptors trkA, trkB, and trkC) were also affected by hormone administration, newborn rats were treated daily with subcutaneous injections of thyroxine until postnatal day 12 (P12) at latest. Control animals received corresponding injections of saline. The pups were sacrificed at defined intervals from P9 to P14. The septal areas and the hippocampi were analyzed using the reverse-transcription polymerase chain reaction (RT-PCR) method for quantification of p75, trkA, trkB, and trkC mRNA levels. Analysis of variance over the total investigation period revealed no significant general increases of the gene expressions of either neurotrophin receptor, neither in the septum nor in the hippocampus, although previous results have shown marked changes in neurotrophin levels. On particular postnatal days, significant upregulation could be observed in hippocampus for trkB and trkC. From these and recent data, we conclude that modulation of neurotrophin expression rather than neurotrophin-receptor expression contributes to the morphological modifications within the hippocampal mossy fiber system and the septo-hippocampal cholinergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050800
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of mRNA expression of the neurotrophins of the nerve growth factor family and their receptors in the septum and hippocampus of rats after transient postnatal thyroxine treatment I. Expression of nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin 4 mRNA (1998)
    Springer
    Experimental brain research 119 (1998), S. 1-8 
    Details
    ISSN: 1432-1106
    Keywords: Key words Thyroid hormone ; Neurotrophins ; Septum ; Hippocampus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Early postnatal application of thyroid hormones to rats results in morphological changes in septum and hippocampus. Modulation in the expression of either neurotrophins and/or their receptors is postulated to be responsible for these effects. In the present study we tested whether thyroxine administration leads to changes in the expression of neurotrophins of the nerve growth factor (NGF) family. Newborn rats were treated daily with subcutaneous injections of thyroxine until postnatal day (P) 12 at maximum. The pups were killed at defined intervals from P2 to 21. The septal area and the hippocampi were analyzed using the reverse transcriptase-PCR method for quantitation of NGF, brain-derived neurotrophic factor (BDNF), NT-3, and NT-4 messenger RNA (mRNA) levels. In hippocampus of hyperthyroid rats, as compared to controls, we found higher levels of BDNF and NT-3 mRNA over the total investigation period, whereas in the septum a thyroxine-dependent increase in NT-3 mRNA expression was observed. In addition, significant thyroxine-induced effects were found for all variables (except for NGF in the septum) at particular postnatal days. From these data we conclude that modulation of neurotrophin expression is a possible mechanism for the morphological modifications within the hippocampal mossy fiber system and the septohippocampal cholinergic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002210050313
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  • 3
    Electronic Resource
    Electronic Resource
    Lack of correlation between changes in cyclic nucleotides and subsequent induction of tyrosine hydroxylase in rat adrenal medulla (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 293 (1976), S. 105-108 
    Details
    ISSN: 1432-1912
    Keywords: cAMP/cGMP ratio ; Tyrosine hydroxylase induction ; Reserpine ; Dexamethasone ; Hypophysectomy ; Adrenal medulla
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pretreatment of rats with dexamethasone (2.5 μmol/kg, a dose which blocks the release of ACTH from the pituitary gland) abolished the reserpine-mediated increase in cAMP and the increase in the cAMP/cGMP ratio in the adrenal medulla. In contrast, the reserpine-mediated induction of tyrosine hydroxylase (TH) remained unchanged. Hypophysectomy had a similar effect to dexamethasone treatment. Since changes in cAMP and changes in the cAMP/cGMP ratio are not indispensible prerequisites for the subsequent induction of TH, a causal relationship between the two phenomena seems to be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498878
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  • 4
    Electronic Resource
    Electronic Resource
    The role of sodium influx mediated by nicotinic receptors as an initial event in trans-synaptic induction of tyrosine hydroxylase in adrenergic neurons (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 313 (1980), S. 199-203 
    Details
    ISSN: 1432-1912
    Keywords: 22Na influx ; Superior cervical ganglion ; Cholinomimetics ; Tyrosine hydroxylase induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. Isolated superior cervical ganglia of the rat were incubated for 2–30 min (37°C) in Krebs' solution or tissue culture medium (BGJb) containing 22Na and then washed for 30 min in ice-cold 22Na-free Krebs' solution (to clear the extracellular space). The radioactivity remaining in the ganglia was taken as a measure of 22Na influx into the intracellular compartment of the ganglion. 2. Addition of cholinomimetics (100 μM nicotine or 100 μM carbachol) to the incubation medium led to an increase in 22Na influx. This increase reached maximal values after 10 min of incubation; it was more pronounced after incubation in Krebs' solution than in BGJb medium. 3. While chlorisondamine (3 μM) or dopamine (100 μM) greatly reduced the carbachol-induced 22Na influx, tetrodotoxin (2 μM) did not have any effect. 4. In ganglia obtained from animals treated with 6-hydroxydopamine in the early postnatal phase (resulting in an extensive destruction of peripheral sympathetic neurons) neither carbachol (100 μM) nor nicotine (100 μM) produced an increase in 22Na influx demonstrating that the intraneuronal compartment is responsible for this enhanced influx. 5. The effects of dopamine, chlorisondamine and tetrodotoxin on the carbachol-induced 22Na uptake into superior cervical ganglia are similar to their effects on carbachol-mediated induction of tyrosine hydroxylase in superior cervical ganglia kept in tissue culture (Thoenen and Otten 1977b). It is concluded that the induction of tyrosine hydroxylase via nicotinic receptors is closely linked to the enhanced sodium influx into the adrenergic neurons mediated by the same receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00505734
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  • 5
    Electronic Resource
    Electronic Resource
    Darstellung von 1,2-Bisalkinylthioether des TetrafluorethansProfessor Ulrich Wannagat zum 65. Geburtstage am 31. Mai 1988 gewidmet (1988)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 560 (1988), S. 55-58 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation of 1,2-Bisalkinylthioether of 1,1,2,2-Tetrafluoroethane1,2-Bisalkinylthioether of 1,1,2,2-tetrafluoroethane are obtained by known procedures with lithiumalkinylides, prepared in situ, and 1,1,2,2-tetrafluoroethane-1,2-bissulfenylchloride.The reactions proceed at low temperatures in non polar solvents. 2a-2e are obtained in acceptable yields. The compounds are air stable but moisture sensitive. The products have been characterized on the basis of n.m.r., i.r., and mass spectra.
    Notes: 1,2-Bisalkinylthioether des 1,1,2,2-Tetrafluorethans werden nach bekannten Verfahren mit in situ hergestellten Lithiumalkinyliden und 1,1,2,2-Tetrafluorethan-1,2,-bissulfenylchlorid 1 erhalten. Die Umsetzungen in unpolaren Lösungsmitteln bei tiefen Temperaturen ergeben die hydrolyseempfindlichen, luftstabilen Verbindungen 2a-2e. Die Produkte werden anhand von NMR-, IR- und Massenspektren charakterisiert.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19885600107
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  • 6
    Electronic Resource
    Electronic Resource
    Darstellung, Struktur und Reaktionen von N,N-Difluorsulfonyl-fluoridamidProfessor K.-H. König zum 60. Geburtstage am 30. Mai 1986 gewidmet (1986)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 539 (1986), S. 191-194 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation, Structure, and Reactions of N,N-DifluorosulfonylfluoridamideFSO2NF2 is obtained in high yield by fluorination of FSO2NH2 at room temperature. The reaction of FSO2NF2 with Et2NH yields FSO2NEt2 and HNF2. The structure of FSO2NF2 was determined by electron diffraction analysis.
    Notes: Die Fluorierung von FSO2NH2 bei Raumtemperatur führt in kurzer Zeit in hoher Ausbeute zu FSO2NF2. Die Umsetzung von FSO2NF2 mit Et2NH liefert FSO2NEt2 und HNF2. Der molekulare Aufbau von FSO2NF2 wurde durch Elektronenbeugung bestimmt. Das Molekül besitzt Cs-Symmetrie. Auffallend ist der relativ lange S—N-Abstand von 175,5(6) pm.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19865390819
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