ISSN:
1420-908X
Keywords:
pH
;
Strong ion difference
;
Weak acid buffers
;
Inorganic phosphate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The interactions between the acid-base variables that contribute to exudate acidosis were studied in the subcutaneous air-pouch after carrageenan injection in rats. We studied the concurrent changes of exudate gases (P CO2 and PO2), main ions ([Na+], [K+], [Ca2+], [Mg2+], [Cl−] and [Lac−]), inorganic phosphate (Pi) and albumin in acutely inflamed rats (4, 8, 12, 24 and 48 h of inflammation). A notable hypercapnia was found in the exudate after only 8 h (exudate PCO2=64.3±2.9 mm Hg) but this hypercapnia decreased after 48 h (32.9±12.7 mm Hg), coincident with the greatest increase in exudate cells. With respect to the metabolic acid-base variables, the most important changes found were a parallel decrease in the strong ion difference ([SID]) and exudate pH, as well as increases in the exudate weak acid buffers ([ATOT]) due to albumin and inorganic phosphate (Pi) increases. However, after 12 h, the exudate acidosis was stable at around pH 7. A similar acid pH was obtained after 24 h of inflammation when the carrageenan solution injected was previously adjusted to a physiological pH (7.4). This pH, analogous to that of the exudate, was the result of compensation by the acid-base independent variables, a fact which suggests that acid pH may be a beneficial condition for cells taking part in inflammatory processes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02252936
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