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  • 1
    Electronic Resource
    Electronic Resource
    Basal and nutrient-stimulated pancreatic and gastrointestinal hormone concentrations in type-l-diabetic patients after successful combined pancreas and kidney transplantation (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 40-48 
    Details
    ISSN: 1432-1440
    Keywords: Pancreas transplantation ; Insulin secretion ; Pancreatic hormones ; Gastrointestinal peptide hormones ; Rènal elimination (clearance) ; Systemic venous pancreas drainage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The secretion of pancreatic and gastrointestinal hormones in the basal state and after nutrient stimuli (50 g glucose, 50 g protein, or 30 g triglyceride administered on separate occasions) was assessed in ten previously type-1-diabetic patients after successful combined kidney and pancreas transplantation (systemic venous drainage). Fasting values were compared to matched non-diabetic kidney-transplanted patients and related to kidney function (endogenous creatinine clearance) and to the type and dosage of immunosuppressive medication. In the fasting state, only IR insulin concentrations were higher in pancreas-kidney-transplanted patients (by 88%; P=0.001) than in the kidney graft recipients. There were significant inverse correlations of plasma C-peptide, GIP, and gastrin immunoreactivity to endogenous creatinine clearance (kidney function). In response to nutrients, insulin secretion (IR insulin, C-peptide) was significantly stimulated by glucose, and — to a lesser degree — also by protein. Pancreatic glucagon was suppressed by glucose and stimulated by protein ingestion. GIP was raised after glucose and triglyceride more than after protein (P=0.0003). GLP-1 immunoreactivity was stimulated by all nutrients, with a tendency towards higher responses to protein and fat (P=0.06). Gastrin was mainly raised by protein. In conclusion, the overall pattern of pancreatic and gastrointestinal hormone release is normal in patients after combined pancreas-kidney-transplantation, but there are some peculiarities due to (a) systemic venous drainage of the pancreas graft (elevated fasting IR insulin) and (b) impaired kidney function (negative correlation of fasting plasma values to endogenous creatinine clearance for C-peptide, GIP, and gastrin). The plasma levels of these important regulatory peptides and their responses to nutrient stimulation are compatible with and may contribute to the well-preserved endocrine function of the pancreatic grafts (normal or slightly impaired glucose tolerance, preserved incretin effect).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422937
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Der Einfluß des Calciums auf den Serumgastrinspiegel und die Magensekretion beim Menschen (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 433-436 
    Details
    ISSN: 1432-1440
    Keywords: Gastrin ; gastric secretion ; calcium ; normal subjects ; duodenal ulcer ; Zollinger-Ellison syndrome ; Gastrin ; Magensekretion ; Calcium ; Normalpersonen ; Ulcus duodeni ; Zollinger-Ellison-Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einfluß einer induzierten Hypercalcämie auf die Serumgastrinspiegel und die Magensekretion wurde bei Normalpersonen, Patienten mit Ulcus duodeni und Patienten mit Zollinger-Ellison-Syndrom untersucht. Bei allen Patientengruppen kommt es während der Calciumgluconatinfusion zu einem signifikanten Anstieg der Serumgastrinspiegel. Patienten mit Ulcus duodeni schütten jedoch 2–3mal soviel Gastrin während einer Hypercalcämie aus wie Normal-personen, während die Gastrinausschüttung bei Patienten mit Zollinger-Ellison-Syndrom ein Vielfaches der von Ulcus duodeni-Patienten beträgt. Die integrierte Säureausschüttung während Hypercalcämie ist bei Ulcus duodeni-Patienten ca. 5fach höher als bei Kontrollpersonen. Diese Untersuchungen zeigen, daß die Calcium-induzierte Magensekretion, zumindestens teilweise, durch eine Gastrinfreisetzung hervorgerufen wird.
    Notes: Summary We studied the effect of hypercalcemia on the serum gastrin concentration and gastric secretion in normal man, duodenal ulcer patients and patients with the Zollinger-Ellison syndrome. All subjects showed a significant increase of serum gastrin concentrations during calcium infusion. Patients with duodenal ulcer showed a 2- to 3-fold higher gastrin output during hypercalcemia than normal subjects, but the gastrin output in patients with Zollinger-Ellison syndrome was much higher compared to patients with duodenal ulcer. The integrated gastric secretory response to hypercalcemia is 5-fold higher in duodenal ulcer patients compared to normal subjects. These studies show that, at least in part, the calcium-induced gastric secretion is caused by gastrin release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468584
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Consequences of systemic venous drainage and denervation of heterotopic pancreatic transplants for insulin/C-peptide profiles in the basal state and after oral glucose (1991)
    Springer
    Diabetologia 34 (1991), S. S81 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; Insulin secretion ; C-peptide ; Systemic venous drainage ; Insulin metabolic clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma glucose, immunoreactive insulin and C-peptide concentrations were compared in nine pancreas-kidney-transplanted patients (systemic venous drainage) and in ten non-diabetic kidney-transplanted patients with similar kidney function. In the basal state, C-peptide (insulin secretion) was similar, but immunoreactive insulin was higher and glucose concentrations were slightly, but significantly lower in pancreas-transplanted patients. After 50 g oral glucose, the plasma glucose and IR-insulin profiles were similar in both groups. The circumvention of first-pass hepatic insulin extraction (decreased endogenous insulin clearance) was compensated for by a significant reduction in insulin secretion (C-peptide; p=0.036). In conclusion, hyperinsulinaemia in pancreas-transplanted patients with systemic venous drainage is significant only in the basal state. Insulin delivered into the portal and peripheral circulation, when leading to similar insulin profiles, maintains comparable degrees of glucose tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587626
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    242. Zollinger-Ellison-Syndrom (1975)
    Springer
    Langenbeck's archives of surgery 339 (1975), S. 755-755 
    Details
    ISSN: 1435-2451
    Keywords: Zollinger-Ellison syndrome, Diagnostic procedure ; Morphology ; Total gastrectomy ; Zollinger-Ellison-Syndrom ; Diagnostik ; Morphologische Befunde Totale Gastrektomie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die klinische Symptomatik, das diagnostische Vorgehen and die Therapie des Zollinger-Ellison-Syndom (Z.E.S.) sind Gegenstand zahlreicher Diskussionen gewesen. Anhand der eigenen Erfahrung bei 13 Fallen werden das Beschwerdebild und die notwendigen diagnostischen MaBnahmen (Serumgastrinbestimmung, Provokationsteste) dargestellt. Die morphologische Vielfalt der gastrinproduzierenden Tumoren wird durch immunhistologische and elektronenmikroskopische Befunde demonstriert. Als Therapie der Wahl hat die totale Gastrektomie zu gelten, da in einem hohen Prozentsatz die Gastrinome bereits metastasiert haben.
    Notes: Summary The clinical symptomatology, diagnostic procedure and treatment of the Zollinger-Ellison syndrome (Z.E.S.) is discussed extensively. The authors' own experience in 13 cases is described to illustrate the symptoms and the necessary diagnostic steps (serum gastrin determination, provocation tests). The morphologic variety of the gastrin-producing tumors is shown by immunohistologic and electron-microscopic findings. Total gastrectomy is the therapy of choice, since most gastrinomas are metastasizing by the time they are recognized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01257721
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    Paper (German National Licenses)
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