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  • 1
    Electronic Resource
    Electronic Resource
    Interaction between d-amphetamine and ethanol with respect to locomotion, stereotypies, ethanol sleeping time, and the kinetics of drug elimination (1978)
    Springer
    Psychopharmacology 59 (1978), S. 143-149 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; Ethanol ; Interaction ; Motility ; Stereotypies ; Sleeping time ; Elimination kinetic of the drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The interaction between d-amphetamine and ethanol with respect to locomotor activity, stereotyped behavior, and sleeping time was investigated in rats. Ethanol 0.8 g/kg i.p. enhanced and prolonged locomotor activity produced by d-amphetamine 1 mg/kg s.c. The increased motility after 5 mg/kg d-amphetamine was not influenced by alcohol 0.8 g/kg i.p. or 3.2 g/kg orally, but slightly protracted. Stereotyped head and paw movements as well as stereotyped licking, were distinctly strengthened and protracted by 3.2 g/kg ethanol orally. The modified d-amphetamine motility and stereotypies can be explained by alcohol-induced prolongation of the life of d-amphetamine. The effect is produced by alcohol's inhibition d-amphetamine p-hydroxylation in rat liver. After 3.2 g/kg ethanol i.p., the sleeping time of male rats amounted to 153 min. Simultaneous administration of 5 mg/kg d-amphetamine s.c. reduced the sleeping time to 84 min. This is obviously based on a central antagonism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427748
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cannabinoids and hexobarbital induced loss of righting reflexes (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 283 (1974), S. 431-435 
    Details
    ISSN: 1432-1912
    Keywords: Tetrahydrocannabinol ; Cannabidiol ; Cannabinol ; Hexobarbital ; Interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of cannabinoids on hexobarbital sleeping time,-blood and-brain levels and on the metabolism of hexobarbital in vitro by rat liver microsomes was investigated. Cannabidiol (CBD) prolongs the hexobarbitone induced loss of righting reflexes stronger than Δ9-tetrahydrocannabinol (THC). The effect of CBD can be explained by an inhibition of the hexobarbital metabolism. It prolongs the half life of the barbiturate in the blood, does not affect the hexobarbital awakening levels in the brain and inhibits strongly the degradation by liver microsomes. The THC-effect, however, is predominantly produced by an interaction in the CNS. THC did not affect the hexobarbital blood levels and was much weaker in inhibiting its degradation in vitro. The awakening levels of the barbiturate in the brain, however, were significantly lowered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501116
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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