ISSN:
0170-2041
Keywords:
1,2-Benzisoselenazol-3(2H)-ones
;
Cytokine inducers
;
Diselenides
;
Interferon-gamma
;
Tumor necrosis factor
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Convenient syntheses of aryl diselenides 2, 1,2-benzisoselenazol-3(2H)-ones 4 and their 1-oxides 7 are reported. Reductive conversions of these compounds to bis(2-carbamoyl)-phenyl diselenides 5 and oxidative cyclization of 5 to 1,2-benzisoselenazol-3(2H)-one 1-oxides 7 as the methods for the synthesis of these compounds are reported. Their ability to induce cytokines, such as TNF and IFN-γ, in human peripheral blood leucocyte cultures is described.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1993199301201
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