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Digitale Medien

Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and traumatic synovitis (1985)

Bendtzen, K. ; Petersen, J. ; Halkjær-Kristensen, J. ; [weitere]

Springer

Rheumatology international 5 (1985), S. 79-82

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Details

ISSN: 1437-160X

Schlagwort(e): Interleukin ; Monocytes/macrophages ; Synovial fluid ; Rheumatoid arthritis ; Traumatic synovitis

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Interleukin-1 (Il-1)-like activity in biological fluids was measured by their ability to rectify the Il-1-dependent lymphokine production of highly purified T lymphocytes to a recall antigen. Il-1-like activity was found in 9 of 11 synovial fluid (SF) specimens from patients with rheumatoid arthritis (RA) but only in 2 of 11 paired RA sera. In traumatic synovitis, low Il-1-like activity was recorded in 5 of 9 SF specimens, and a similar low activity was found in sera of 4 of these patients. The Il-1-like activity was partly absorbed by an anti-Il-1 antibody. The presence of Il-1 in the SF of patients with RA suggests in vivo activation of monocytes/macrophages.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00270301

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