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  • 1
    Electronic Resource
    Electronic Resource
    Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors (1994)
    Springer
    Diabetologia 37 (1994), S. 1036-1043 
    Details
    ISSN: 1432-0428
    Keywords: Key words Insulin action ; pancreatectomy ; glucose uptake ; pancreas transplantation ; minimal model.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Healthy humans undergoing hemipancreatectomy for the purpose of donation to a family member with IDDM have previously been demonstrated to maintain serum glucose values equal to matched control subjects during short-term glucose infusion despite significant decrements in glucose- and arginine-induced insulin secretion. In order to determine whether humans compensate for hemipancreatectomy by increasing insulin- or glucose-mediated glucose uptake, we measured glucose turnover and insulin sensitivity by three protocols. Insulin-mediated glucose uptake was measured during sequential infusions of insulin at rates of 0.25, 1.0, and 10.0 mU · kg−1· min−1 in 12 donor subjects and 12 matched control subjects maintained at euglycaemia. Both groups displayed similar increases in rates of glucose disappearance and similar decreases in rates of hepatic glucose production. Glucose-mediated uptake was calculated as the difference between the rates of glucose disappearance measured during a hyperglycaemic clamp and a euglycaemic clamp performed at identical rates of insulin infusion and was also found to be similar in both donor subjects and control subjects. Both groups also had indistinguishable measures of insulin sensitivity and glucose effectiveness as determined by the minimal model technique. Therefore, donor subjects appear to compensate for diminished insulin secretion following hemipancreatectomy by an unidentified mechanism since neither insulin- nor glucose-mediated glucose uptake are increased. [Diabetologia (1994) 37: 1036–1043]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400467
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Insulin-mediated and glucose-mediated glucose uptake following hemipancreatectomy in healthy human donors (1994)
    Springer
    Diabetologia 37 (1994), S. 1036-1043 
    Details
    ISSN: 1432-0428
    Keywords: Insulin action ; pancreatectomy ; glucose uptake ; pancreas transplantation ; minimal model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Healthy humans undergoing hemipancreatectomy for the purpose of donation to a family member with IDDM have previously been demonstrated to maintain serum glucose values equal to matched control subjects during short-term glucose infusion despite significant decrements in glucose- and arginine-induced insulin secretion. In order to determine whether humans compensate for hemipancreatectomy by increasing insulin- or glucose-mediated glucose uptake, we measured glucose turnover and insulin sensitivity by three protocols. Insulin-mediated glucose uptake was measured during sequential infusions of insulin at rates of 0.25, 1.0, and 10.0 mU·kg−1·min−1 in 12 donor subjects and 12 matched control subjects maintained at euglycaemia. Both groups displayed similar increases in rates of glucose disappearance and similar decreases in rates of hepatic glucose production. Glucose-mediated uptake was calculated as the difference between the rates of glucose disappearance measured during a hyperglycaemic clamp and a euglycaemic clamp performed at identical rates of insulin infusion and was also found to be similar in both donor subjects and control subjects. Both groups also had indistinguishable measures of insulin sensitivity and glucose effectiveness as determined by the minimal model technique. Therefore, donor subjects appear to compensate for diminished insulin secretion following hemipancreatectomy by an unidentified mechanism since neither insulin- nor glucose-mediated glucose uptake are increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400467
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Structure predicts synaptic function of two classes of interneurons in the thoracic ganglia of Locusta migratoria (1987)
    Springer
    Cell & tissue research 250 (1987), S. 105-114 
    Details
    ISSN: 1432-0878
    Keywords: Interneurons ; Neuronal connections ; Neuroanatomy ; Locusta migratoria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The relationship between synaptic function and structure was examined for 32 spiking interneurons (13 inhibitory and 19 excitatory) in the meso- and metathoracic ganglia of the locust, Locusta migratoria. In no instance was the structure of an excitatory interneuron similar to that of an inhibitory interneuron. However, 12 of the 13 inhibitory interneurons shared a number of structural features, namely a ventromedially located soma, axon(s) projecting into contralateral connective(s), and a laterally bowed primary neurite. Structurally the excitatory interneurons formed a more heterogeneous group. Even so, 12 of the 19 had a combination of structural features in common, namely laterally located somata and axon(s) projecting into contralateral connective(s). The clear differences in structure of the two main groups of inhibitory and excitatory interneurons suggest that other neurons with structures similar to members of these two groups can be classified as inhibitory and excitatory, respectively. Thus we propose that structure predicts synaptic function for two distinct groups of interneurons in the thoracic ganglia of locusts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214661
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    GABA-like immunoreactivity of identified interneurons in the flight system of the locust, Locusta migratoria (1988)
    Springer
    Cell & tissue research 254 (1988), S. 331-340 
    Details
    ISSN: 1432-0878
    Keywords: GABA ; Interneurons ; Flight ; Immunohistochemistry ; Locusta migratoria (Insecta)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The transmitter content of identified inhibitory interneurons in the flight system of the locust, Locusta migratoria, has been characterized using antibodies raised against protein-conjugated gamma aminobutyric acid. Identified flight neurons were filled with the fluorescent dye, Lucifer Yellow. Serial sections of dye-filled neurons were incubated with an antibody to gamma aminobutyric acid which was subsequently tagged with a fluorescent marker. Excitatory motoneurons to wing muscles and 13 flight interneurons (3 excitatory, 7 inhibitory, and 3 with unknown synaptic effect) were examined. Neither the moto-neurons nor any of the 3 excitatory interneurons contained immunoreactive material. Six of the 7 inhibitory interneurons did contain immunoreactive material. All the neurons which contained immunoreactive material and whose synaptic effect is known were inhibitory. We conclude that most of the inhibitory flight interneurons which have been described use gamma aminobutyric acid as their transmitter. Interestingly, at least 1 set of interneurons known to be inhibitory does not use gamma aminobutyric acid. We predict that the 2 interneurons which do contain immunoreactive material and whose synaptic effect is not yet known will be found to have inhibitory roles in the operation of the flight circuitry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225805
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    Paper (German National Licenses)
    Fulltext
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