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  • Interstitial lung disease  (1)
  • Key words: Allergic asthma—T-lymphocytes—Cytokines—Granulocytes—Chemotaxis—Interleukin-5—Corticosteroids.  (1)
  • Key words: Cytokines—mRNA—Bronchoalveolar lavage cells—Asthma  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Role of haematological, pulmonary and renal complications in the long-term prognosis of patients with lysinuric protein intolerance (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 437-440 
    Details
    ISSN: 1432-1076
    Keywords: Lysinuric protein intolerance ; Erythroblastophagocytosis ; Interstitial lung disease ; Renal disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three patients with lysinuric protein intolerance are reported. The first patient displayed severe haemolytic anaemia, bone marrow erythroblastophagocytosis, renal tubular disease and interstitial lung disease. Despite treatment with citrulline and low-protein diet, this child died at the age of 18 months. The second patient is now 24 years old and has chronic interstitial lung disease and focal renal glomerulosclerosis. The third patient, now 5 years old, has severe chronic interstitial lung disease. A 6-month treatment with prednisone was ineffective in the second and third patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955906
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Budesonide Down-Regulates Eosinophil Locomotion But Has No Effects on ECP Release or on H2O2 Production (1999)
    Springer
    Lung 177 (1999), S. 219-228 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Allergic asthma—T-lymphocytes—Cytokines—Granulocytes—Chemotaxis—Interleukin-5—Corticosteroids.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Treatment of allergic asthma with inhaled corticosteroids results in local down-regulation of proinflammatory cytokine synthesis and in marked decrease in tissue eosinophilia. Blood concentrations of inhaled corticosteroids, although significantly lower than those measured in the lung, may still have antiinflammatory effects on circulating eosinophils, reducing their ability to migrate. The aim of our study was to evaluate in vitro the activity of budesonide on blood eosinophils by measuring their chemotactic response, eosinophil cationic protein (ECP) release, and hydrogen peroxide (H2O2) production in the presence of different drug concentrations similar to those obtained at airway level (10−8 and 10−7 M) and at blood level (10−10 and 10−9 M). Partially purified blood eosinophils, isolated from 23 asthmatic subjects, were used to evaluate the activity of budesonide on: (1) chemotaxis toward the activated fifth component of complement (C5a, 0.1 μg/ml) or recombinant human (rh) interleukin (IL)-5 (200 pg/ml), (2) ECP release by cells stimulated with tetradecanoylphorbol acetate (TPA) and (3) H2O2 production by TPA-activated cells. The chemotactic response to C5a was down-regulated significantly by budesonide only by the highest concentrations tested (10−8 and 10−7 M); differently, budesonide was effective in inhibiting eosinophil migration toward rhIL-5, at all concentrations tested (p 〈 0.01, each comparison). By contrast, no drug-induced modifications were observed in ECP release or in H2O2 production (p 〉 0.05, each comparison). We conclude that concentrations of budesonide similar to those obtained in vivo are effective in inhibiting eosinophil locomotion but not in down-regulating the release of reactive oxygen species and granule-associated proteins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007642
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Expression of Cytokine mRNA in Bronchoalveolar Lavage Cells from Atopic Asthmatics before Late Antigen-Induced Reaction (1997)
    Springer
    Lung 175 (1997), S. 195 -209 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Cytokines—mRNA—Bronchoalveolar lavage cells—Asthma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Recently, much attention has been given to the possible role of lymphocytes and their soluble products in causing and maintaining allergic inflammation. The aim of this study was to assess the production of mRNAs for interleukins (IL) in bronchoalveolar lavage (BAL) cells obtained from allergic asthmatics after challenge with the relevant allergen in the period between early and late reactions. We evaluated BAL fluid cells obtained from six asthmatic subjects and four nonatopic controls. Challenge was performed with the relevant allergen. BAL fluid cells were obtained by fiberoptic bronchoscopy and bronchoalveolar lavage. To detect mRNA encoding each cytokine in BAL cells we used a reverse transcriptase polymerase chain reaction method. We evaluated IL-1α, -2, -4, -5, -6, -13, and granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon-γ (IFN-γ). mRNAs for IL-1α, -2, -4, -5, and IFN-γ were detected in all of the atopic subjects; mRNAs for IL-6 and GM-CSF were found in five asthmatics; and mRNA for IL-13 was found in one patient only. In contrast, no mRNAs for IL-2, -4, -5, -6, -13, and GM-CSF were detected in the nonatopic healthy controls; mRNA for IL-1α was found in one out of four normal subjects; and mRNA for IFN-γ was evidenced in two of four subjects. The cellular environment in BAL fluids from allergic asthmatics before the clinical appearance of the late airway reaction shows an unrestricted expression of mRNA for cytokines. The local cytokine milieu could have an important role in the modulation of bronchial inflammation and in the appearance of allergic symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007567
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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